DNA Microarray placement for improved performance and reliability
DNA Microarray placement for improved performance and reliability
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DNA 微阵列放置可提高性能和可靠性
DOI：
10.1109/vdat.2010.5496742
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
D. Pan
中科院分区：
文献类型：
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作者：
Anurag Kumar;Minsik Cho;D. Pan
DNA微阵列或DNA芯片已成为鉴定DNA序列（基因或基因突变），基因丰度和其他基因组分析的标准方法。 DNA微阵列由小型DNA片段（探针）组成，这些片段（探针）是使用掩模和类似于VLSI工业的光刻方法制造的。但是，光刻制造技术由于意外照明导致探针中的错误导致微阵列的性能和可靠性降低。在本文中，我们提出了一种使用度量标准进行微阵列的放置方法。我们提出了基于希尔伯特 - 曲线填充的探针放置，其中包含性能指标。实验结果表明，使用我们的方法，探针的杂交电势（导致更高的性能和可靠性）提高了57倍。
DNA Microarrays or DNA chips have become a standard method for identification of DNA sequence (genes or gene mutation), determination of abundance of genes and other genomic analysis. DNA Microarrays are composed of small DNA fragments (probes) which are manufactured using masks and photolithographic method similar to VLSI industry. However, photolithographic manufacturing technology introduces errors in the probes due to unintended illumination leading to reduced performance and reliability of the Microarray. In this paper, we present a placement method using a metric for performance of microarray. We propose a Hilbert-curve filling based probe placement which incorporates the performance metric. Experimental results show upto 57x increase in the hybridization potential (leading to higher performance and reliability) of the probes on using our method.