Chronic obstructive pulmonary disease in never-smoking dairy farmers.
Chronic obstructive pulmonary disease in never-smoking dairy farmers.
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DOI：
10.2174/1874306401509010059
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mijakoski D
中科院分区：
文献类型：
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作者：
Stoleski S;Minov J;Karadzinska-Bislimovska J;Mijakoski D
与工作相关的慢性阻塞性肺疾病(COPD)在全球疾病负担中占相当大的比例。目的了解不吸烟奶农慢性阻塞性肺疾病的患病率及特点。我们对75名年龄在26岁到59岁之间的男性奶农进行了一项横断面研究，并将他们与年龄和工作年限相似的同等数量的男性办公室职员进行了比较。通过问卷调查获得慢性呼吸道症状、职业史、日常生活活动等资料。接受检查的受试者的肺功能测试包括基线肺活量测定和支气管扩张剂可逆性测量。奶农的总体呼吸道症状患病率较高，但咳嗽、痰和呼吸困难的患病率有显著差异。奶农有更普遍的与工作有关的呼吸道症状，总体症状、咳嗽和痰明显。奶农肺活量参数的平均基线值较低，但FEV1/FVC%、MEF50、MEF75和MEF25-75有显著差异。奶农的COPD患病率显著高于办公室对照(10.7%比2.7%，P=0.049)。奶农和办公室控制人员显示COPD与45岁以上的年龄显著相关。奶农的慢性阻塞性肺病与工龄20年以上有显著相关性(P=0.023)，与工作相关的慢性呼吸道症状也有相关性(P=0.041)。这项研究结果有利于奶农工作暴露于呼吸危害和持续呼吸道阻塞之间的因果关系。
Work-related chronic obstructive pulmonary disease (COPD) represents a considerable part of the disease burden globally. To assess the COPD prevalence and characteristics in never-smoking dairy farmers. We have conducted a cross-sectional study with 75 male dairy farmers aged 26 to 59 years, and compared them with equivalent number of male office workers similar by age, and duration of employment. Data on chronic respiratory symptoms, job history and daily activities were obtained by questionnaire. Lung functional testing of the examined subjects included baseline spirometry, and bronchodilator reversibility measurement. Dairy farmers showed higher prevalence of overall respiratory symptoms, but significant difference was noticed for cough, phlegm, and dyspnea. Dairy farmers had more prevalent work-related respiratory symptoms, being significant for overall symptoms, cough, and phlegm. The mean baseline values of spirometric parameters were lower in dairy farmers, but significance was reported for FEV1/FVC%, MEF50, MEF75, and MEF25-75. Dairy farmers had significantly higher COPD prevalence than office controls (10.7% vs 2.7%, P = 0,049). Dairy farmers and office controls showed significant association between COPD and age over 45 years. Dairy farmers had a significant association between COPD and employment duration of over 20 years (P = 0.023), but also between COPD and work-related chronic respiratory symptoms (P = 0.041). The study findings favor the cause-effect association between job exposure to respiratory hazards, and development of persistent airway obstruction among dairy farmers.