Physical activity and breast cancer risk: The women's health study (United states)
Physical activity and breast cancer risk: The women's health study (United states)
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DOI：
10.1023/a:1008948125076
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发表时间：
2001-02-01
影响因子：
2.3
通讯作者：
Buring, JE
中科院分区：
文献类型：
--
作者：
Lee, IM;Rexrode, KM;Buring, JE
目的：身体活动降低乳腺癌风险在生物学上是合理的；然而，流行病学研究得出了不一致的结果。因此，我们在女性健康研究中检查了身体活动和乳腺癌风险。方法：我们评估了 39,322 名年龄大于或等于 45 岁、表面健康的女性的身体活动，并对她们进行了平均 48 个月的前瞻性跟踪。 411 名女性罹患乳腺癌，其中 222 名雌激素和孕激素受体均呈阳性。 结果：在所有女性中，与娱乐活动和爬楼梯消耗量 < 840、840-2519、2520-6299 以及大于或等于 6300 kJ/周相关的所有乳腺癌的多变量相对风险分别为 1.00（参考）、1.04（95%）置信区间分别为 0.77-1.40)、0.86 (0.64-1.17) 和 0.80 (0.58-1.12)； p 趋势 = 0.11。然而，在绝经后女性中，所有乳腺癌都存在显着的相反趋势；相应的相对风险分别为1.0（参考）、0.97（0.68-1.4）、0.78（0.54-1.1）和0.67（0.44-1.0）； p 趋势 = 0.03。在所有女性或绝经后女性中，体力活动与雌激素和孕激素受体均呈阳性的乳腺癌无关（p 趋势分别 = 0.50 和 0.26）。当我们仅评估需要大于或等于 6 MET 或静息代谢率倍数的剧烈娱乐活动时，我们发现，无论是在所有女性还是绝经后女性中，与所有乳腺癌或类固醇激素受体阳性乳腺癌没有显着相关性。 结论：这些数据表明，中年和老年期间的体力活动与降低乳腺癌风险并不完全相关。仅在绝经后女性中，较高水平的体力活动可能会降低患乳腺癌的风险。然而，这项研究的统计能力有限，无法检测到微小的影响。
Objective: It is biologically plausible for physical activity to decrease breast cancer risk; however, epidemiologic studies have yielded inconsistent findings. We therefore examined physical activity and breast cancer risk in the Women's Health Study.Methods: We assessed physical activity among 39,322 apparently healthy women, aged greater than or equal to 45 years, and prospectively followed them for an average of 48 months. Four hundred eleven women developed breast cancer, with 222 positive for both estrogen and progesterone receptors.Results: Among all women the multivariate relative risks of all breast cancer associated with < 840, 840-2519, 2520-6299, and greater than or equal to 6300 kJ/week expended on recreational activities and stair climbing were 1.00 (referent), 1.04 (95% confidence interval, 0.77-1.40), 0.86 (0.64-1.17), and 0.80 (0.58-1.12), respectively; p-trend = 0.11. However, among postmenopausal women there was a significant inverse trend for all breast cancer; the corresponding relative risks were 1.0 (referent), 0.97 (0.68-1.4), 0.78 (0.54-1.1), and 0.67 (0.44-1.0), respectively; p-trend = 0.03. Physical activity was unrelated to breast cancers positive for both estrogen and progesterone receptors either among all or postmenopausal women (p-trend = 0.50 and 0.26, respectively). When we assessed only vigorous recreational activity, requiring greater than or equal to6 METs or multiples of resting metabolic rate, we observed no significant associations with all or steroid hormone receptor positive breast cancer, either among all or postmenospausal women.Conclusions: These data suggest that physical activity during middle age and older is not uniformly associated with decreased breast cancer risk. Among postmenopausal women only, higher levels of physical activity may decrease the risk of breast cancer. This study, however, had limited statistical power to detect small effects.