β-Cell MicroRNAs: Small but Powerful.
β-Cell MicroRNAs: Small but Powerful.
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作者：
Filios SR;Shalev A
非编码RNA，特别是microRNAs(MiRs)已经成为细胞生物学中包括发育、分化和生存在内的关键过程的重要调节因子。目前，已有超过2500个成熟的miR在人类中被报道，考虑到每个miR有多个靶点，潜在影响的基因和途径的数量是巨大的。不足为奇的是，许多MIR也与糖尿病有关，最近，一些MIR被发现在胰岛中发挥重要作用，包括β细胞功能、增殖和生存。这一视角的目的是提供对这一快速发展的领域和涉及的MIR的概述，揭示β-CELL MIR信号的新网络，并展望未来的机遇和挑战。
Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of genes and pathways potentially affected is huge. Not surprisingly, many miRs have also been implicated in diabetes, and more recently, some have been discovered to play important roles in the pancreatic islet, including β-cell function, proliferation, and survival. The goal of this Perspective is to offer an overview of this rapidly evolving field and the miRs involved, reveal novel networks of β-cell miR signaling, and provide an outlook of the opportunities and challenges ahead.