Tubular Secretion Markers, Glomerular Filtration Rate, Effective Renal Plasma Flow, and Filtration Fraction in Healthy Adolescents.
Tubular Secretion Markers, Glomerular Filtration Rate, Effective Renal Plasma Flow, and Filtration Fraction in Healthy Adolescents.
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DOI：
10.1016/j.xkme.2020.05.013
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发表时间：
2020-09
期刊：
影响因子：
3.9
通讯作者：
Bjornstad P
中科院分区：
文献类型：
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作者：
Seegmiller JC;Wolfe BJ;Albtoush N;Melena I;Gross SP;Vinovskis C;Ix JH;Bjornstad P
在临床实践中，肾脏疾病的诊断和预后仍然局限于通过血清肌酐和/或胱抑素C测定肾小球滤过率（GFR）和尿白蛋白测定肾小球完整性评估。对全球肾脏健康和功能进行更广泛的评估将大大改善临床实践和研究方法，特别是如果这种测量可以减少侵入性。肾脏功能的一个关键方面是肾血和血浆流向肾脏的输送。有效肾血浆流量（ERPF）可以通过输注对氨基马嘌呤（PAH）来测量。多环芳烃由近端小管细胞高保真地分泌，当以低浓度输注时，大多数通过肾脏被一次清除，从而近似于ERPF。评估ERPF的研究是艰巨的，很少进行，因为需要几个小时的静脉输注才能达到稳定的状态和准确的定时采集血液和/或尿液。近年来，ERPF研究很少，因为可注射的多环芳烃（PAH）尚未商业化，需要美国食品和药物管理局（fda）的新药研究申请。
The diagnosis and prognosis of kidney disease in clinical practice remain limited to estimation of glomerular filtration rate (GFR) by serum creatinine and/or cystatin C measurements and glomerular integrity assessment with urinary albumin measurement. A broader assessment of global kidney health and function would substantially improve clinical practice and research methods, especially if such measurements could be made less invasively.One critical aspect of kidney function is delivery of renal blood and plasma flow to the kidneys. Effective renal plasma flow (ERPF) can be measured by infusion of p-aminohippurate (PAH). PAH is secreted with high fidelity by the proximal tubule cells, with most cleared by a single pass through the kidney when infused at a low concentration, thus approximating ERPF. 1 Studies evaluating ERPF are arduous and rarely performed due to the required intravenous infusion for several hours to achieve steady state and accurate timed collections of blood and/or urine. In recent years, ERPF studies are scarce because injectable PAH is not commercially available and requires US Food and Drug Administration Investigational New Drug application.
影响因子：
19.6
作者：
Dowling, TC;Frye, RF;Matzke, GR
通讯作者：
Matzke, GR
影响因子：
13.6
作者：
Suchy-Dicey, Astrid M.;Laha, Thomas;Kestenbaum, Bryan R.
通讯作者：
Kestenbaum, Bryan R.
影响因子：
19.6
作者：
通讯作者：
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