The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless.
The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless.
复制标题
含有乙醇脱氢酶结构基因的果蝇常染色体小区域的遗传学。
作者：
M. Ashburner
一个致死位点（l（2）br 7; 35 B6 -10）位于D.被鉴定为Plunkett无毛（H）的显性抑制基因。在8个新等位基因中，7个为H的显性抑制基因，第8个为H的显性增强基因。其中一个抑制基因是H的泄漏致死和弱抑制基因。如Nash（1970）所述，l（2）br 7的缺失是H的显性抑制因子，而重复是H的显性增强因子。提出了一个简单的模型来解释l（2）br 7和H的相互作用，假设l（2）br 7的无定形（或亚晶）等位基因抑制H，而超晶等位基因增强H。
A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak suppressor of H. Confirming Nash (1970), deletions of l(2)br7 are dominant suppressors, and duplications are dominant enhancers of H. A simple model is proposed to account for the interaction of l(2)br7 and H, assuming that amorphic (or hypomorphic) alleles of l(2)br7 suppress H and that hypermorphic alleles enhance H.