What have genomic and proteomic approaches told us about vitamin D and cancer?
What have genomic and proteomic approaches told us about vitamin D and cancer?
复制标题
关于维生素 D 和癌症，基因组学和蛋白质组学方法告诉我们什么？
DOI：
10.1111/j.1753-4887.2007.tb00340.x
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发表时间：
2007
影响因子：
6.1
通讯作者：
Fleet,JamesC
中科院分区：
文献类型：
--
作者：
Fleet,JamesC
There is a large amount of interest in the potential cancer chemopreventative and therapeutic actions of vitamin D, its metabolites, and vitamin D analogs. 1 However, while we have traditionally viewed the active hormonal form of vitamin D, 1, 25-dihydroxyvitamin D or 1, 25 (OH) 2D, as an agent that causes growth arrest, promotes differentiation, and stimulates apoptosis, the molecular targets mediating these interactions are not known definitively. Discovery of these vitamin D-regulated molecular targets has been limited by the traditional approaches to cell and molecular biology. Luckily, in the last decade we have seen the dawning of a new era in biology. The Human Genome Project and its ancillary technologies such as the DNA microarray and computational biology now permit us to take a systems approach to questions of biology and disease etiology. 2 The classic flow of biological information from gene-to-transcript to protein-to-function has been turned from a single gene, reductionist paradigm into a broad, global evaluation of the pattern of changes and regulatory events necessary for changes in a biological system. In theory, this approach can reveal the responses and relationships of all elements in a functioning biological system, and it has been successfully applied in model organisms such as yeast to advance our understanding of areas such as mineral3 and amino acid metabolism. 4
