Habituation and migraine
Habituation and migraine
复制标题
DOI：
10.1016/j.nlm.2008.07.006
复制
发表时间：
2009-09-01
影响因子：
2.7
通讯作者：
Schoenen, Jean
中科院分区：
文献类型：
--
作者：
Coppola, Gianluca;Pierelli, Francesco;Schoenen, Jean
偏头痛患者发作间期最常见的异常表现是神经元信息处理缺乏习惯性。其潜在机制尚不确定。神经元兴奋性增加，抑制或减少预激活水平都被认为是可能的罪魁祸首。本综述总结了现有的数据习惯性偏头痛患者获得不同的方法学途径。我们将讨论在偏头痛周期中习惯化水平的变化，我们将表明这些数据一致地表明偏头痛患者的感觉皮层对重复的刺激反应过度，而不是对一系列小的刺激反应过度。尽管这种高反应性的精确细胞和分子机制仍然必须确定，我们将描述实验数据，表明由于单胺能控制不足而引起的节律失调的丘脑-皮层活动可能是一个合理的解释。(C)2008年爱思唯尔公司All rights reserved.
The most reproducible and ubiquitous interictal abnormality of the migraineurs' brain is lack of habituation in neuronal information processing. The underlying mechanisms are uncertain. Increased neuronal excitability, decreased inhibition or decreased pre-activation levels have all been proposed as possible culprits.The present review summarizes the available data on habituation in migraine patients obtained with different methodological approaches. We will discuss the change of habituation level over the migraine cycle and we will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to a small series of stimuli.Although the precise cellular and molecular mechanisms of this hyper-responsivity must still be determined, we will describe experimental data suggesting that a dysrhythmic thalamo-cortical activity due to inadequate monoaminergic control might be a plausible explanation. (C) 2008 Elsevier Inc. All rights reserved.