Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum:: A new class of potent anti-HIV agents
Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum:: A new class of potent anti-HIV agents
复制标题
DOI：
10.1016/s0040-4039(99)00339-1
复制
发表时间：
1999-04-09
影响因子：
1.8
通讯作者：
Lee, KH
中科院分区：
文献类型：
--
作者：
Duan, HQ;Takaishi, Y;Lee, KH
从昆明山海棠（Tripterygium hypoglaucum（Levl.）哈奇通过波谱分析和X射线衍射等手段鉴定了其结构。雷公藤甲素（1）和次甘草素（B-3）（4）显示出有效的抗HIV活性，EC 50值分别为2.54和0.13 μ g/ml，治疗指数值分别为39.4和>1000。(C)1999 Elsevier Science Ltd.保留所有权利。
Two new sesquiterpene polyol esters (triptonine A and B) with alkaloid and monoterpene were isolated from Tripterygium hypoglaucum (Levl.) Hutch. Their structures were elucidated by spectroscopic means and X-ray analysis. Triptonine A (1) and hypoglaunine B-3) (4) demonstrated potent anti-HIV activity with EC50 values of 2.54 and 0.13 mu g/ml and therapeutic index values of 39.4 and >1000, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.