Antigenic relationships among the newer myxoviruses (parainfluenza).
Antigenic relationships among the newer myxoviruses (parainfluenza).
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较新的粘病毒（副流感）之间的抗原关系。
DOI：
10.1093/oxfordjournals.aje.a119998
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发表时间：
1959
影响因子：
--
通讯作者：
R. Chanock
中科院分区：
文献类型：
--
作者：
M. Cook;B. Andrews;H. Fox;H. Turner;W. James;R. Chanock
通过补体结合、病毒中和和血凝抑制试验研究了粘病毒组成员之间的抗原关系。研究的病毒包括甲型、B和丙型流感病毒、仙台病毒、1型和2型血细胞吸附（HA）病毒、哮吼相关（CA）病毒、腮腺炎和纽卡斯尔病（NDV）。未证明甲型、B或丙型流感病毒与本研究中纳入的其余粘病毒之间存在抗原相关性。除仙台病毒和HA 2病毒外，用混合豚鼠抗血清进行的补体结合试验未显示交叉反应。这两种病毒之间的交叉反应并不完全是相互的，并且在用仙台抗血清进行的试验中特别明显，表明这两种病毒共有的抗原在仙台的浓度高于HA。病毒仙台和HA 3病毒之间的抗原关系也被证明，但在较低程度上，通过病毒抗原的补体结合试验，血凝抑制和血清中和。仙台病毒和HA 2病毒被认为是相同病毒类型的亚型。在用来自单个豚鼠的抗血清或用人恢复期血清进行的补体结合试验中，揭示了仙台病毒、腮腺炎病毒、CA、HA和NDV之间的低水平交叉反应。thisBulletin，1959，v.34，1056]，其中该组的新成员以副流感粘病毒的名称聚集，具有由M. para-influenzae 1（仙台和HA）、M. paraïnfluenzae 2（CA）和M.副流感病毒3（HA 1）H. G.佩雷拉。
Antigenic relationships among members of the Myxovirus group were studied by means of complement-fixation, virus neutralization and haemagglutination-inhibition tests. The viruses investigated included influenza A, B and C, Sendai, haemadsorption (HA) viruses types 1 and 2, croup-associated (CA) virus, mumps and Newcastle disease (NDV). No antigenic relation could be demonstrated between influenza A, B or C and the remaining Myxoviruses included in this study. Complement-fixation tests performed with pooled guineapig antisera failed to show cross reactions, except in the case of Sendai and HA2viruses. Cross-reactions between these 2 viruses were not entirely reciprocal, and were particularly marked in tests performed with Sendai antiserum suggesting that an antigen common to these 2 viruses is present in higher concentration in Sendai than in HA., virus. An antigenic relationship between Sendai and HA3virus was also demonstrated, but to a lower extent, by complement-fixation tests with viral antigens, by haem-agglutination-inhibition and by serum neutralization. Sendai and HA2viruses are considered to be sub-types of the same virus type. Low levels of cross reactions between Sendai, mumps, CA, HA and NDV were revealed in complement-fixation tests done with antisera from individual guineapigs or with human convalescent sera.The present findings support the recently proposed classification of Myxoviruses [ANDREWESet al., thisBulletin, 1959, v. 34, 1056] in which the new members of the group are gathered under the nameMyxovirus parainfluenzaewith 3 subgroups consisting ofM. para-influenzae1 (Sendai and HA,),M. paraïnfluenzae2 (CA) andM. paraïnfluenzae3 (HA1)H. G. Pereira.