Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome.
Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome.
复制标题
DOI：
10.1007/s11894-011-0195-7
复制
发表时间：
2011-08-01
影响因子：
--
通讯作者：
Corinaldesi, Roberto
中科院分区：
文献类型：
--
作者：
Barbara, Giovanni;Cremon, Cesare;Corinaldesi, Roberto
内脏超敏反应目前被认为是一个关键的病理生理机制，涉及疼痛的感觉在大亚组的功能性胃肠道疾病，包括肠易激综合征（IBS）的患者。在IBS中，20%-90%的患者描述了内脏高敏感性。中枢神经系统和心理因素对IBS患者内脏高敏感性的贡献可能是显著的，尽管仍有争议。在认识到感染性肠炎可能引发持续性IBS症状的发展以及粘膜免疫、神经、内分泌、微生物和肠通透性异常的鉴定之后，外周因素获得了越来越多的关注。越来越多的证据表明，这些因素在IBS患者的大子集中通过感觉神经通路从外周到大脑的疼痛传递中起重要作用。在这篇综述中，我们将报告有关IBS内脏高敏感性机制的最新数据，特别关注外周机制。
Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral hypersensitivity has been described in 20%-90% of patients. The contribution of the central nervous system and psychological factors to visceral hypersensitivity in patients with IBS may be significant, although still debated. Peripheral factors have gained increasing attention following the recognition that infectious enteritis may trigger the development of persistent IBS symptoms, and the identification of mucosal immune, neural, endocrine, microbiological, and intestinal permeability abnormalities. Growing evidence suggests that these factors play an important role in pain transmission from the periphery to the brain via sensory nerve pathways in large subsets of patients with IBS. In this review, we will report on recent data on mechanisms involved in visceral hypersensitivity in IBS, with particular attention paid to peripheral mechanisms.