Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection
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DOI：
10.1038/s41467-019-13467-w
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发表时间：
2019-12-04
影响因子：
16.6
通讯作者：
Lee, John Richard
中科院分区：
文献类型：
--
作者：
Magruder, Matthew;Sholi, Adam N.;Lee, John Richard
大多数尿路细菌感染的起源通常被认为是肠道。在此，我们研究肠道微生物群与菌尿和尿路感染（UTI）的未来发展之间的关系。我们使用16 S rRNA基因深度测序对来自168名肾移植受者的510份粪便标本进行肠道微生物分析，并对粪便标本和尿液上清液标本的子集进行宏基因组测序。我们报告说，1%的相对肠道丰度的大肠埃希氏菌是一个独立的危险因素，大肠埃希氏菌尿症和UTI和1%的相对肠道丰度的肠球菌是一个独立的危险因素，肠球菌菌尿症。菌株分析建立了相同受试者肠道和尿液中发现的菌种之间的密切菌株水平对齐。我们的研究结果支持肠道微生物群-UTI轴，表明调节肠道微生物群可能是预防UTI的潜在新策略。
The origin of most bacterial infections in the urinary tract is often presumed to be the gut. Herein, we investigate the relationship between the gut microbiota and future development of bacteriuria and urinary tract infection (UTI). We perform gut microbial profiling using 16S rRNA gene deep sequencing on 510 fecal specimens from 168 kidney transplant recipients and metagenomic sequencing on a subset of fecal specimens and urine supernatant specimens. We report that a 1% relative gut abundance of Escherichia is an independent risk factor for Escherichia bacteriuria and UTI and a 1% relative gut abundance of Enterococcus is an independent risk factor for Enterococcus bacteriuria. Strain analysis establishes a close strain level alignment between species found in the gut and in the urine in the same subjects. Our results support a gut microbiota-UTI axis, suggesting that modulating the gut microbiota may be a potential novel strategy to prevent UTIs.