Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.
Habenula-prefrontal resting-state connectivity in reactive aggressive men - A pilot study.
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反应性侵略性男性中的Habenula-Prefrental静止状态 - 一项试点研究。
DOI：
10.1016/j.neuropharm.2018.10.025
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发表时间：
2019-09-15
影响因子：
4.7
通讯作者：
Alia-Klein N
中科院分区：
文献类型：
--
作者：
Gan G;Zilverstand A;Parvaz MA;Preston-Campbell RN;d'Oleire Uquillas F;Moeller SJ;Tomasi D;Goldstein RZ;Alia-Klein N
对挑衅的过度愤怒和反应性攻击是间歇性爆炸障碍（IED）的核心症状。先前的研究表明，健康个体的攻击倾向与在没有挑衅的情况下，前额叶边缘和默认模式网络（DMN）在休息时功能的改变有关。在一项初步研究中，我们使用静息状态功能磁共振成像来研究男性（以IED为例）明显的反应性攻击对静息状态大脑网络的功能组织的影响，包括皮层下淋巴结，如先前在临床前模型中与攻击有关的缰带。图论应用于静息状态网络，以确定与低反应性攻击性男性（对照组）相比，高反应性攻击性男性的整体效率和聚类的变化。此外，我们计算了特征攻击与图测量之间的组内相关性，以及特征攻击与缰核静息状态功能连接（rsFC）之间的组内全脑种子-体素回归分析。与对照组相比，反应性攻击性男性的左缰核、丘脑左侧枕核、左背外侧前额叶皮层和右颞极的整体效率更高，DMN节点的聚集性也有下降的趋势。在反应性攻击组中，高水平的特质攻击与较低的左束整体效率以及较低的左束与左腹外侧前额叶皮层（一个参与抑制控制的核心区域）之间的rsFC有关。结合临床前证据，我们在男性中的发现强调了异常的缰-前额叶连通性与攻击行为严重程度的相关性。
Disproportionate anger and reactive aggression in response to provocation are core symptoms of intermittent-explosive disorder (IED). Previous research shows a link between the propensity for aggression in healthy individuals and altered functioning of prefrontal-limbic and default-mode networks (DMN) at rest when no provocation is present. In a pilot study, we used resting-state functional magnetic resonance imaging to investigate the effects of pronounced reactive aggression in men, exemplified by IED, on the functional organization of resting-state brain networks including subcortical nodes such as the habenula previously implicated in aggression in preclinical models. Graph theory was applied to resting-state networks to determine alterations in global efficiency and clustering in high reactive aggressive men compared to low reactive aggressive men (controls). Further, we computed within-group correlations between trait aggression and graph measures, as well as within-group whole-brain seed-to-voxel regression analyses between trait aggression and habenula resting-state functional connectivity (rsFC). Reactive aggressive men compared to controls showed higher global efficiency in the left habenula, the left pulvinar in the thalamus, the left dorso-lateral prefrontal cortex, and the right temporal pole, as well as a trend for decreased clustering in DMN nodes. In the reactive aggressive group, high levels of trait aggression were linked to lower global efficiency of the left habenula, and to lower rsFC between the left habenula and the left ventro-lateral prefrontal cortex, a core region involved in inhibitory control. Together with preclinical evidence, our findings in men underline the relevance of aberrant habenula-prefrontal connectivity for the severity of aggressive behavior.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
3.7
作者：
Alia-Klein N;Preston-Campbell RN;Moeller SJ;Parvaz MA;Bachi K;Gan G;Zilverstand A;Konova AB;Goldstein RZ
通讯作者：
Goldstein RZ
社会大脑：社会知识的神经基础。
影响因子：
24.8
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Crossley, Nicolas A.;Mechelli, Andrea;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.