Multiple sclerosis and gluten sensitivity
Multiple sclerosis and gluten sensitivity
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DOI：
10.1016/j.clineuro.2007.04.011
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发表时间：
2007-10-01
影响因子：
1.9
通讯作者：
Lankarani, Kamran B.
中科院分区：
文献类型：
--
作者：
Borhani-Haghighi, Afshin;Ansari, Neda;Lankarani, Kamran B.
目的：比较多发性硬化症(MS)患者和健康对照组的面筋敏感频率。患者和方法：选择2004年3月至2005年10月在伊朗南部设拉子市Nemazee医院神经科门诊就诊的161例临床确诊的MS患者。用酶免疫分析法(EIA)检测血清中抗醇溶蛋白抗体。对血清IgA、IgG型AGA均阳性的患者进行IgA抗跨组织谷氨酰胺酶(TTG)检测和十二指肠活检。对166例年龄、性别匹配的对照组进行抗胶质蛋白抗体检测。结果：抗胶质蛋白抗体在NIS患者组和对照组之间均无显著差异。抗TTG抗体和组织病理学检查均为阴性，且抗胶质蛋白抗体均为阳性。不同性别、年龄、病程和功能受累的NIS患者血清中抗脂肪抗体的平均值无显著差异。结论：面筋敏感性与伊朗的MS无关。(C)2007 Elsevier B.V.保留所有权利。
Objective: To compare the frequency of gluten sensitivity in patients with multiple sclerosis (MS) and healthy controls.Patients and Methods: The patients were 161 clinically definite MS patients who referred to neurology outpatient clinic of Nemazee Hospital, Shiraz, south of Iran from March 2004 to October 2005. IgG and IgA antigliadin antibodies were measured by enzyme immuno assay (EIA) method. The test of IgA antitranstissue glutaminase (tTG) and duodenal biopsy were carried out in patients with either IgA or IgG AGA positive sera. Anti-liadin antibodies were also measured for 166 age and sex matched control group.Results: Neither IgG nor IgA antigliadin antibodies showed significant differences between NIS patients and controls. Anti-tTG antibody and histopathologic studies were negative in all patients with positive IgG or IgA antigliadin antibodies results. Mean values of IgG and IgA antialiadin antibodies in NIS patients with different sex, age, course, and functional systems involvement were not significantly different.Conclusion: Gluten sensitivity is not associated with MS in Iran.(c) 2007 Elsevier B.V. All rights reserved.