Renal sympathetic nerve activity is increased in obese Zucker rats.

Renal sympathetic nerve activity is increased in obese Zucker rats.
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DOI：
10.1161/01.hyp.25.4.834
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发表时间：
1995-04
期刊：
Hypertension
影响因子：
8.3
通讯作者：
Donald A. Morgan;E. A. Anderson;A. Mark
Donald A. Morgan;E. A. Anderson;A. Mark
中科院分区：
医学1区
文献类型：
--
作者：
Donald A. Morgan;E. A. Anderson;A. Mark

文献摘要

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在遗传性肥胖的Zucker大鼠中发现，棕色脂肪组织的交感神经活动（SNA）水平较低，并可能通过降低产热作用促进肥胖。相反，据报道，获得性肥胖与SNA增加有关。为了确定肥胖Zucker大鼠的低SNA水平是否会延伸到肾脏，我们比较了喂食低盐（0.4% NaCl）和高盐（8.0% NaCl）饮食2周的肥胖和瘦弱有意识的Zucker大鼠肾脏SNA的基线水平。根据死亡前清醒状态下、静息状态下和死亡后获得的多纤维记录计算肾脏SNA基线。肥胖大鼠（n = 17）的平均体重为490 +/- 12 g（平均+/- SEM），瘦大鼠（n = 19）的平均体重为339 +/- 7 g。喂食低盐饮食的肥胖和瘦Zucker大鼠的平均动脉压没有差异。然而，在高盐饮食中，肥胖大鼠（n = 8）的平均动脉压显著高于瘦大鼠（n = 9）（分别为113 +/- 3和101 +/- 3 mm Hg， P < 0.05）。各组肥胖大鼠的基线肾SNA约为瘦大鼠的2 ~ 2.5倍（P < 0.05）。这些研究表明，肥胖的Zucker大鼠对肾脏的SNA水平升高，而对棕色脂肪组织的SNA水平降低。
A low level of sympathetic nerve activity (SNA) to brown adipose tissue has been found in genetically obese Zucker rats and may promote obesity through decreased thermogenesis. In contrast, acquired obesity is reportedly associated with increased SNA. To determine whether low SNA levels in obese Zucker rats extend to the kidney, we compared baseline levels of renal SNA in obese and lean conscious unrestrained Zucker rats fed for 2 weeks on low salt (0.4% NaCl) and high salt (8.0% NaCl) diets. Baseline renal SNA was calculated from multifiber recordings obtained before death under conscious, resting conditions and after death. Body weight averaged 490 +/- 12 g (mean +/- SEM) in obese rats (n = 17) and 339 +/- 7 g in lean rats (n = 19). Mean arterial pressure did not differ in obese and lean Zucker rats fed the low salt diet. However, on the high salt diet, mean arterial pressure was significantly higher in obese rats (n = 8) than in lean rats (n = 9) (113 +/- 3 and 101 +/- 3 mm Hg, respectively; P < .05). Baseline renal SNA was approximately 2 to 2.5 times higher (P < .05) in obese rats than in lean rats in all groups. These studies suggest that obese Zucker rats have heightened levels of SNA to the kidney in contrast to reduced SNA to brown adipose tissue.