Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI
Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI
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DOI：
10.1038/ejhg.2008.272
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发表时间：
2009-08-01
影响因子：
5.2
通讯作者：
Davey-Smith, George
中科院分区：
文献类型：
--
作者：
Shugart, Yin Yao;Chen, Lina;Davey-Smith, George
本研究旨在探讨脑源性神经营养因子(BDNF)Val66Met基因多态性与体重指数(BMI)的关系。这两个人群是：英国妇女心脏与健康研究(BWHHS)(年龄60-79岁)和雅芳亲子纵向研究(16-44岁)的母亲。我们对这两个人群中的Val66Met多态(Rs6265)进行了基因分型，并进行了线性回归分析，以检验该多态与BMI之间的关联。两个研究人群均显示体重指数与Val66Met基因多态有关，携带蛋氨酸-蛋氨酸基因的个体的平均体重指数低于ValMet或ValVal型(在体重健康组)：平均体重指数差值=-0.911 kg/m(2)，95%可信区间：-1.7~-0.12，P=0.023；在雅芳亲子纵向研究的母亲中：平均体重指数差=-0.57 kg/m(2)，95%可信区间：-1.08~-0.054，P=0.03)。在对这两项研究的合并分析中，以及另一项以合适的格式提供数据以纳入我们的荟萃分析的研究中，我们发现成年女性的合并差异为-0.76(95%CI：-1.16，-0.036)；I-2-异质性检验为51%，P=0.13。我们的研究表明，在两项关于女性的一般人群研究中，脑源性神经营养因子和体重指数之间存在关联。BDNF在体重调节中的确切作用值得进一步研究。《欧洲人类遗传学杂志》(2009年)1710501055；DOI：10.1038/ejhg.2008.272；在线发布2009年2月11日
The goal of this study is to investigate the relationship between the Val66Met polymorphism in the brain-derived neurotrophic factor ( BDNF) and body mass index ( BMI) in two sizable and well-characterized populations of British women: the British Women's Heart and Health Study ( BWHHS) ( age 60-79 years) and the mothers from the Avon Longitudinal Study of Parents and Children ( age 16-44 years). We genotyped the Val66Met polymorphism ( rs6265) in these two populations, and conducted a linear regression analysis to test for an association between this polymorphism and BMI. Both study populations indicated an association between BMI and the Val66Met polymorphism, with individuals carrying the Met-Met genotype having a lower mean BMI than those with the Val-Met or Val-Val genotypes ( in the BWHHS): mean BMI difference =-0.911 kg/m(2), 95% confidence interval ( CI): -1.70 to -0.12, P=0.023; in the mothers from the Avon Longitudinal Study of Parents and Children ( ALSPAC): mean BMI difference = -0.57 kg/m(2), 95% CI: -1.08 to -0.054, P=0.03). In a pooled analysis of these two studies, together with one further published study that provided data in a suitable format for inclusion in our meta-analysis, we found a pooled difference of -0.76 ( 95% CI: -1.16, -0.036) for adult women; I-2-test for heterogeneity 51%, P=0.13. Our study indicated an association between BDNF and BMI in two general population studies of women. The exact role of BDNF in weight regulation merits further investigation. European Journal of Human Genetics ( 2009) 17, 1050-1055; doi:10.1038/ejhg.2008.272; published online 11 February 2009