Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women.
Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women.
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DOI：
10.3967/0895-3988.2012.04.004
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发表时间：
2012-08
期刊：
影响因子：
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通讯作者：
Ou Wang;Min Nie;Ying Ying Hu-Ying;Kui Zhang;Wei Li;Fan Ping;Jun Tao Liu;Li Meng Chen;X. Xing
中科院分区：
文献类型：
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作者：
Ou Wang;Min Nie;Ying Ying Hu-Ying;Kui Zhang;Wei Li;Fan Ping;Jun Tao Liu;Li Meng Chen;X. Xing
目的探讨孕妇维生素D缺乏与妊娠期糖尿病(GDM)发病风险的关系。方法采用巢式病例对照研究。对200例妊娠期糖尿病(GDM)患者和200例糖耐量正常(NGT)患者的临床和生化资料进行分析。结果妊娠期糖尿病组和非妊娠期糖尿病组的血清25-羟基维生素D(25OHD)水平中位数分别为22.39(17.67，29.38)和25.86(19.09，34.88)nmol/L。GDM组25OHD缺乏或功能不全的发生率显著高于NGT组。与维生素D水平较高的受试者相比，摄氧量<25nmol/L的受试者患妊娠期糖尿病的风险高1.8倍。在GDM组中，调整混杂因素后，血清25OHD与HbA1c和胰岛素抵抗独立相关。在NGT组中，在调整了母亲年龄和其他混杂因素后，血清25OHD与空腹血糖和收缩压独立相关。结论25OHD缺乏症在中国女性中非常普遍。低25OHD状态可能与胰岛素抵抗有关，并可能是GDM的危险因素。
OBJECTIVE To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus (GDM) in pregnant Chinese women. METHODS A nested case-control study was conducted. Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance (NGT). RESULTS The median (interquartile range) serum 25-hydroxyvitamin D (25OHD) levels were 22.39 (17.67, 29.38) and 25.86 (19.09, 34.88) nmol/L in the GDM and NGT groups, respectively. Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group. Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels. In the GDM group, serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors. In the NGT group, serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors. CONCLUSION 25OHD insufficiency is very common in Chinese women. Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM.