Sympathetic neural reactivity to mental stress in offspring of hypertensive parents: 20 years revisited
Sympathetic neural reactivity to mental stress in offspring of hypertensive parents: 20 years revisited
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DOI：
10.1152/ajpheart.00378.2016
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发表时间：
2016-08-01
影响因子：
4.8
通讯作者：
Carter, Jason R.
中科院分区：
文献类型：
--
作者：
Fonkoue, Ida T.;Wang, Min;Carter, Jason R.
最近的一些研究已经强调了人类肌肉交感神经活动（MSNA）对精神压力的反应性的个体间差异。本研究的目的是检查血压（BP）和MSNA对精神压力的反应性，在一个大型的和可推广的队列中，有和没有高血压家族史（FHH）的年轻人。我们假设，受试者与FHH将表现出更大的交感神经兴奋的精神压力比受试者没有FHH。对最近发表（n = 45）和正在进行（n = 42）的研究中的共87例受试者（55例男性和32例女性，年龄18-40岁）进行了检查; 57例受试者（19例FHH和38例无FHH）在基线时有完整的MSNA记录。在仰卧位休息5分钟和精神应激（心算）5分钟期间记录心率（HR）、BP和MSNA。静息MSNA和HR在有和无FHH的受试者之间无统计学差异（P > 0.05），而静息平均动脉压在有FHH的受试者中更高（86 +/- 2 vs. 80 +/- 1 mmHg，P < 0.05）。精神应激使FHH受试者的MSNA增加（Δ 5 +/- 1爆发/分钟），而非FHH受试者的MSNA没有增加[Δ 1 +/- 1爆发/分钟，P < 0.01（时间X组）]。精神应激使FHH组和非FHH组的平均动脉压（Delta 12 +/- 1和Delta 10 +/- 1 mmHg，P < 0.001）和心率（Delta 19 +/- 2和Delta 16 +/- 2 beats/min，P < 0.001）增加，但两组间无差异[P >= 0.05（时间X组）]。MSNA和BP对精神压力的反应在两组中均不相关。总之，FHH与MSNA对精神压力的反应性升高相关，尽管MSNA和BP反应性之间存在分离。
A number of recent studies have highlighted large interindividual variability of muscle sympathetic nerve activity (MSNA) responsiveness to mental stress in humans. The purpose of this study was to examine blood pressure (BP) and MSNA responsiveness to mental stress in a large and generalizable cohort of young adults with and without family history of hypertension (FHH). We hypothesized that subjects with FHH would demonstrate greater sympathoexcitation to mental stress than subjects without FHH. A total of 87 subjects (55 men and 32 women, 18-40 yr of age) from recently published (n = 45) and ongoing (n = 42) studies were examined; 57 subjects (19 with FHH and 38 without FHH) had complete MSNA recordings at baseline. Heart rate (HR), BP, and MSNA were recorded during 5 min of supine rest and 5 min of mental stress (mental arithmetic). Resting MSNA and HR were not statistically different between subjects with and without FHH (P > 0.05), whereas resting mean arterial pressure was higher in subjects with FHH (86 +/- 2 vs. 80 +/- 1 mmHg, P < 0.05). Mental stress increased MSNA in subjects with FHH (Delta 5 +/- 1 bursts/min), but not in subjects without FHH [Delta 1 +/- 1 burst/min, P < 0.01 (time X group)]. Mental stress increased mean arterial pressure (Delta 12 +/- 1 and Delta 10 +/- 1 mmHg, P < 0.001) and HR (Delta 19 +/- 2 and Delta 16 +/- 2 beats/min, P < 0.001) in subjects with and without FHH, but these increases were not different between groups [P >= 0.05 (time X group)]. MSNA and BP reactivity to mental stress were not correlated in either group. In conclusion, FHH was associated with heightened MSNA reactivity to mental stress, despite a dissociation between MSNA and BP responsiveness.