A SUMOylation wave to anchor the genome.
A SUMOylation wave to anchor the genome.
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DOI:
10.1083/jcb.202110031
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发表时间:
2021-12-06
期刊:
影响因子:
--
通讯作者:
Marston AL
中科院分区:
文献类型:
--
作者:
Marston AL
Marston discusses work from the Wozniak laboratory showing that mitotic phosphorylation triggers a wave of SUMOylation at the nuclear envelope to re-establish chromatin tethers in late mitosis. Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103036) identify a phosphorylation and SUMOylation-dependent cascade that links chromatin to the nuclear membrane during late mitosis.
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期刊:
The Journal of cell biology
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