A SUMOylation wave to anchor the genome.

A SUMOylation wave to anchor the genome.
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DOI:
10.1083/jcb.202110031
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发表时间:
2021-12-06
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Marston AL
Marston AL
中科院分区:
其他
文献类型:
--
作者:
Marston AL

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马斯顿讨论了沃兹尼亚克实验室的工作,该工作表明有丝分裂磷酸化触发核包膜上的SUMOylation波,以在有丝分裂后期重建染色质系链。在有丝分裂过程中,为了促进染色体分离,核膜上的染色质链会丢失。这些连接如何重新建立以确保间期的功能基因组组织尚不清楚。Ptak et al.(2021)。[j]细胞生物学。https://doi.org/10.1083/jcb.202103036)鉴定磷酸化和sumoylation依赖性级联,在有丝分裂后期将染色质连接到核膜。
Marston discusses work from the Wozniak laboratory showing that mitotic phosphorylation triggers a wave of SUMOylation at the nuclear envelope to re-establish chromatin tethers in late mitosis. Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103036) identify a phosphorylation and SUMOylation-dependent cascade that links chromatin to the nuclear membrane during late mitosis.
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