Silk-based electrospun tubular scaffolds for tissue-engineered vascular grafts
Silk-based electrospun tubular scaffolds for tissue-engineered vascular grafts
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DOI：
10.1163/156856208784089607
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Leisk, Gary
中科院分区：
文献类型：
--
作者：
Soffer, Leah;Wang, Xianyan;Leisk, Gary
采用静电纺丝技术，以桑蚕丝素蛋白为原料，采用全水溶液法制备了非织造纳米纤维管状支架。对静电纺丝管进行了细胞研究和机械特性测试，以评估其在生物工程小直径血管移植物中使用的可行性。成功地将人血管内皮细胞和平滑肌细胞培养在静电纺丝上。机械表征试验证明爆破强度足以承受动脉压力，拉伸性能与自体血管相当。这些细胞和力学结果证明了这些静电纺丝支架用于小直径血管移植物的潜在效用。
Electrospinning was used to fabricate non-woven nanofibrous tubular scaffolds from Bombyx mori silk fibroin using an all aqueous process. Cell studies and mechanical characterization tests were performed on the electrospun silk tubes to assess the viability of their usage in bioengineering small-diameter vascular grafts. Human endothelial cells and smooth muscle cells were successfully cultured on the electrospun silk. Mechanical characterization tests demonstrated burst strength sufficient to withstand arterial pressures and tensile properties comparable to native vessels. These cellular and mechanics outcomes demonstrate potential utility of these electrospun silk scaffolds for small-diameter vascular grafts.