Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers
Alcohol use, urinary cortisol, and heart rate variability in apparently healthy men: Evidence for impaired inhibitory control of the HPA axis in heavy drinkers
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DOI：
10.1016/j.ijpsycho.2005.10.013
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发表时间：
2006-03-01
影响因子：
3
通讯作者：
Fischer, JE
中科院分区：
文献类型：
--
作者：
Thayer, JF;Hall, M;Fischer, JE
酗酒和大量饮酒与许多生理、行为、情感和认知问题有关。其中一个问题涉及下丘脑-垂体-肾上腺（HPA）轴的失调，酗酒者表现出较高的基础皮质醇水平和降低的抑制性反馈控制。此外，饮酒与心率变异性（HRV）降低有关。在本研究中，我们研究了542名表面健康的男性饮酒，皮质醇排泄和HRV之间的关系。与饮酒量较低的两个三分位数的男性相比，自我报告饮酒量最高的三分位数的男性皮质醇水平较高，心率变异性较低。此外，皮质醇和心率变异性之间的负相关关系大大减弱，即使在大量饮酒组占了一些潜在的混杂因素。这些结果支持以前的研究在酗酒者的HPA轴失调，并建议受损的抑制控制的HPA轴酗酒者。这些发现与神经内脏整合模型相一致，该模型将中枢和外周过程联系起来，并可能为未来调查包括大量饮酒表型的生理，行为，情感和认知因素的复杂组合提供全面的框架。(c)2005年由Elsevier B. V.出版
Alcoholism and heavy drinking are associated with a number of physiological, behavioral, affective, and cognitive problems. One Such problem involves dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, with alcoholics showing higher basal cortisol levels and reduced inhibitory feedback control. In addition, alcohol consumption is associated with decreased heart rate variability (HRV). In the present study we examined the relationships among alcohol consumption, cortisol excretion, and HRV in 542 apparently healthy men. Men in the top tertile of self-reported alcohol consumption had higher cortisol levels and lower HRV compared to men in the lower two tertiles of alcohol consumption. In addition, the inverse relationship between cortisol and HRV was greatly attenuated in the heavy drinking group even after accounting for a number of potential confounding factors. These results support prior research on the HPA axis dysregulation in alcoholics and suggest impaired inhibitory control of the HPA axis in heavy drinkers. The findings are consistent with the neurovisceral integration model, which links central and peripheral processes, and may provide a comprehensive framework for the future investigation of the complex mix of physiological, behavioral, affective, and cognitive factors which comprise the heavy drinking phenotype. (c) 2005 Published by Elsevier B.V.