Wolbachia spread dynamics in stochastic environments
Wolbachia spread dynamics in stochastic environments
复制标题
沃尔巴克氏体在随机环境中的传播动态
DOI：
10.1016/j.tpb.2015.09.003
复制
发表时间：
2015-12-01
影响因子：
1.4
通讯作者：
Zheng, Bo
中科院分区：
文献类型：
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作者：
Hu, Linchao;Huang, Mugen;Zheng, Bo
登革热是一种由蚊子传播的病毒性疾病，每年有1亿人感染。一种控制登革热的新策略是利用沃尔巴克氏体细菌入侵登革热媒介伊蚊。由于环境异质性对自然区域沃尔巴克氏体传播动态的影响很少被量化，我们开发了一个微分方程模型，该模型的环境条件在两个制度之间随机切换。我们发现了一些惊人的现象，随机政权过渡可以驱动沃尔巴克氏体灭绝从某些初始状态证实沃尔巴克氏体固定在均匀的环境中，蚊子释放促进沃尔巴克氏体入侵更有效地当政权过渡频繁。通过叠加在每个政权定义的ODE系统的相空间，我们确定的阈值曲线以下，沃尔巴克氏体入侵整个人口，扩展阈值感染频率的理论随机环境。(C)2015 Elsevier Inc. All rights reserved.
Dengue fever is a mosquito-borne viral disease with 100 million people infected annually. A novel strategy for dengue control uses the bacterium Wolbachia to invade dengue vector Aedes mosquitoes. As the impact of environmental heterogeneity on Wolbachia spread dynamics in natural areas has been rarely quantified, we develop a model of differential equations for which the environmental conditions switch randomly between two regimes. We find some striking phenomena that random regime transitions could drive Wolbachia to extinction from certain initial states confirmed Wolbachia fixation in homogeneous environments, and mosquito releasing facilitates Wolbachia invasion more effectively when the regimes transit frequently. By superimposing the phase spaces of the ODE systems defined in each regime, we identify the threshold curves below which Wolbachia invades the whole population, which extends the theory of threshold infection frequency to stochastic environments. (C) 2015 Elsevier Inc. All rights reserved.