Retinal circadian rhythms in humans.
Retinal circadian rhythms in humans.
复制标题
人类视网膜昼夜节律。
DOI：
10.1081/cbi-100107971
复制
发表时间：
2001
影响因子：
2.8
通讯作者：
Youngstedt,SD
中科院分区：
文献类型：
--
作者：
Tuunainen,A;Kripke,DF;Cress,AC;Youngstedt,SD
视网膜中的昼夜节律可以反映眼睛中的内在节律。以前的报告昼夜变化的电生理人类视网膜的措施已经很少，结果有些不一致。我们研究了受试者在36小时测试期间的眼电图（EOG）、视网膜电图（ERG）和视觉阈值（VTH）的昼夜变化。我们使用超短睡眠-觉醒周期来平衡昼夜节律周期中睡眠和明暗的影响。12名健康志愿者（10名男性，2名女性;平均年龄26.3岁，标准差[SD] 8.0岁，范围19-40岁）参加了研究。每90分钟测量一次视网膜功能和口腔温度。EOG在光照下测量，而ERG和VTH在黑暗中测量。睡眠是从Actillume监测器检测到的活动中推断出来的。EOG峰-峰反应遵循昼夜节律，峰值出现在上午晚些时候（峰值12：22）。ERG b波隐式时间在清晨达到峰值（06：46）。在ERG a波隐式时间或峰-峰振幅中未显示统计学显著的昼夜节律。VTH节律在清晨达到峰值（蓝色刺激的峰期为07：59，红色刺激的峰期为07：32）。所有的视网膜节律表现出不太一致的acrophase比温度和睡眠节律。这项研究表明，几种不同的昼夜节律的视网膜电生理和心理物理措施的健康受试者。由于视网膜节律的信噪比比温度节律差得多，因此不能推荐这些措施作为昼夜节律标记。（国际时间生物学，18（6），957 - 971，2001）
Circadian rhythms in the retina may reflect intrinsic rhythms in the eye. Previous reports on circadian variability in electrophysiological human retinal measures have been scanty, and the results have been somewhat inconsistent. We studied the circadian variation of the electrooculography (EOG), electroretinography (ERG), and visual threshold (VTH) in subjects undergoing a 36h testing period. We used an ultrashort sleep-wake cycle to balance effects of sleep and light-dark across circadian cycles. Twelve healthy volunteers (10 males, 2 females; mean age 26.3 years, standard deviation [SD] 8.0 years, range 19–40 years) participated in the study. The retinal functions and oral temperature were measured every 90 min. The EOG was measured in the light, whereas the ERG and the VTH were measured in the dark. Sleep was inferred from activity detected by an Actillume monitor. The EOG peak-to-peak responses followed a circadian rhythm, with the peak occurring late in the morning (acrophase 12:22). The ERG b-wave implicit time peaked in the early morning (acrophase 06:46). No statistically significant circadian rhythms could be demonstrated in the ERG a-wave implicit time or peak-to-peak amplitude. The VTH rhythm peaked in the early morning (acrophases 07:59 for blue and 07:32 for red stimuli). All retinal rhythms showed less-consistent acrophases than the temperature and sleep rhythms. This study demonstrated several different circadian rhythms in retinal electrophysiological and psychophysical measures of healthy subjects. As the retinal rhythms had much poorer signal-to-noise ratios than the temperature rhythm, these measures cannot be recommended as circadian markers. (Chronobiology International,18(6),957–971,2001)