Recent advances and perceptions in studies of heterodimerization between G protein-coupled receptors
Recent advances and perceptions in studies of heterodimerization between G protein-coupled receptors
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DOI：
10.2174/092986608783744207
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发表时间：
2008-03-01
影响因子：
1.6
通讯作者：
Sakai, Tsubasa
中科院分区：
文献类型：
--
作者：
Satake, Honoo;Sakai, Tsubasa
G蛋白偶联受体（GPCR）可形成异源二聚体或异源寡聚体，其生物化学和/或药理学活性与相应的单体或同聚体不同。最近的体外和体内实验数据也显示了几种孤儿GPCR作为异源二聚体的调节单位的新功能作用和开发异源二聚体选择性临床药物的潜力。本文综述了GPCR异二聚化反应的基本原理和最新进展，以及目前需要解决的问题。
G pretein coupled-receptors (GPCR) have been shown to form heterodimers or heterooligomers with various biochemical and/or pharmacological activity that are distinct from those of the corresponding monomers or homomers. Recent in vitro and in vivo experimental data have also shown novel functional roles of several orphan GPCRs as modulatory units of heterodimers and potentials for development of heterodimer-selective clinical agents. In this review, we summarize essential and latest knowledge as to GPCR heterodimerizations and the current issues to be solved in the near future.