[Study on the mechanism of Bushen Culuan Chongji treating "kidney deficiency and blood stasis" in ovulatory dysfunctional infertility].
[Study on the mechanism of Bushen Culuan Chongji treating "kidney deficiency and blood stasis" in ovulatory dysfunctional infertility].
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DOI：
10.19540/j.cnki.cjcmm.20171012.004
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发表时间：
2017-12-01
期刊：
影响因子：
--
通讯作者：
Li, Min
中科院分区：
文献类型：
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作者：
Ma, Kun;Li, Min
肾虚血瘀是排卵障碍性不孕的主要病因。肾虚是其主要病理机制。血瘀是本病的主要病理表现，是贯穿始终的重要因素。补肾促排卵冲剂是在传统中医理论指导下，结合多年临床经验，结合无排卵性不孕症的病因病机及现代药理研究成果，精选而成，既保持了中医辨证分型及不同疾病的特点，又体现了病证结合的优越性。补肾促排卵冲剂治疗无排卵性不孕症的研究中，无急性毒性，未检测到LD_（50）。在生殖、遗传、毒性、致畸和围产期试验中，高、低剂量组均未发现不良反应和副作用。在药效学实验中，它能促进大鼠卵泡的发育成熟和黄体的形成。以肾虚血瘀证为切入点，系统研究异常子宫出血-排卵障碍、多囊卵巢综合征、高泌乳素、未破裂卵泡黄素化综合征、黄体期缺陷、卵巢储备功能减退/卵巢早衰等6种排卵功能障碍性不孕症的疗效、安全性及机制。验证了补肾化瘀中药的贡献程度，体现了辨病与辨证相结合的特点，诠释了异病同治的治疗原则，为临床治疗提供了科学依据。
Kidney deficiency and blood stasis is the main cause of ovulatory dysfunctional infertility. Kidney deficiency is the main pathological mechanism. Blood stasis is the main pathological manifestation, and it is an important factor throughout. Bushen Culuan Chongji is under the guidance of traditional Chinese medicine(TCM) theory, previous years of clinical experience, combined with the etiology and pathogenesis of anovulatory infertility and modern pharmacological research results, selected, not only maintains the TCM syndrome differentiation and different diseases features, but also reflects the superiority of the combination of disease. In the study of Bushen Culuan Chongji in the treatment of anovulatory infertility, there was no acute toxicity and no LD50 was detected. No adverse effects and side effects were found in the reproductive, genetic, toxicity, teratogenic, and perinatal tests in their high and low dose groups. In pharmacodynamics experiments, it can promote the development and maturation of follicles and the formation of corpus luteum in rats. Taking the kidney deficiency and blood stasis syndrome as the breakthrough point, systematically study the efficacy, safety and mechanism of six ovulatory dysfunctional infertility diseases, including abnormal uterine bleeding-ovulatory disorders, polycystic ovary syndrome, high prolactin, luteinized unruptured follicle syndrome, luteal phase defect and diminished ovarian reserve/premature ovarian failure. It verified the contribution degree of reinforcing kidney and resolving stasis TCM, reflected the characteristics of combination between disease differentiation and syndrome differentiation, interpreted the treatment principles of treating different diseases with the same method, and provided scientific basis for clinical treatment.