PERMEABILITY BARRIER TO RIFAMPIN IN MYCOBACTERIA
PERMEABILITY BARRIER TO RIFAMPIN IN MYCOBACTERIA
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DOI：
10.1128/aac.11.5.773
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发表时间：
1977-01-01
影响因子：
4.9
通讯作者：
KAJIOKA, R
中科院分区：
文献类型：
--
作者：
HUI, J;GORDON, N;KAJIOKA, R
分离到一株对利福平具有天然耐药性的胞内分枝杆菌。发现核糖核酸聚合酶对利福平敏感。吐温80的研究表明，在完整的生物体中存在针对利福平的渗透性屏障。被认为对利福平耐药的耻垢分枝杆菌ATCC 607型菌株也表现出渗透屏障。利福平耐药性在自然发生的分枝杆菌菌株和可变水平的耐药菌株的某些物种的这种生物体是由于渗透性障碍的可能性进行了讨论。
A strain ofMycobacterium intracellularethat exhibited natural resistance to rifampin was isolated. The ribonucleic acid polymerase was found to be susceptible to rifampin. Studies with Tween 80 suggested that a permeability barrier against rifampin was present in the intact organism. A type strain ofMycobacterium smegmatis, ATCC 607, considered resistant to rifampin also demonstrated a permeability barrier. The possibility that rifampin resistance in naturally occurring strains of mycobacteria and variable levels of resistance in strains of certain species of this organism are due to permeability barriers is discussed.