Population receptive fields of ON and OFF thalamic inputs to an orientation column in visual cortex
Population receptive fields of ON and OFF thalamic inputs to an orientation column in visual cortex
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DOI：
10.1038/nn.2729
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发表时间：
2011-02-01
影响因子：
25
通讯作者：
Alonso, Jose M.
中科院分区：
文献类型：
--
作者：
Jin, Jianzhong;Wang, Yushi;Alonso, Jose M.
灵长类动物和食肉动物的初级视觉皮层被组织成具有类似刺激取向偏好的神经元柱，但这种组织的发育起源和功能仍然存在争议。我们发现皮质柱的取向偏好与其丘脑输入的ON和OFF的群体接受野密切相关。来自丘脑输入的接受野散射比之前认为的更有限，并且与皮层输入层神经元的平均接受野大小相匹配。此外，丘脑群体感受野（以ON - OFF平均值计算）具有独立的ON和OFF亚区，类似于第4层的皮质神经元，并提供了对柱首选方向的准确预测。这些结果支持了定向图的发育模型，该模型基于对皮层的on和OFF视觉输入的接受野安排。
The primary visual cortex of primates and carnivores is organized into columns of neurons with similar preferences for stimulus orientation, but the developmental origin and function of this organization are still matters of debate. We found that the orientation preference of a cortical column is closely related to the population receptive field of its ON and OFF thalamic inputs. The receptive field scatter from the thalamic inputs was more limited than previously thought and matched the average receptive field size of neurons at the input layers of cortex. Moreover, the thalamic population receptive field (calculated as ON - OFF average) had separate ON and OFF subregions, similar to cortical neurons in layer 4, and provided an accurate prediction of the preferred orientation of the column. These results support developmental models of orientation maps that are based on the receptive field arrangement of ON and OFF visual inputs to cortex.