Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis
Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis
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二十二碳六烯酸，保护素合成：与动脉粥样硬化血栓形成的相关性
DOI：
10.1017/s0029665113003704
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发表时间：
2014-05-01
影响因子：
7
通讯作者：
Guichardant, Michel
中科院分区：
文献类型：
--
作者：
Lagarde, Michel;Liu, Miao;Guichardant, Michel
DHA是一种来自海洋脂质的丰富营养素：考虑到剂量效应，已在人类志愿者中研究了其特定的生物学效应。我们在此报告，在剂量低于1克/天，DHA被证明是有效的降低血小板功能，并表现出“抗氧化”的效果。然而，在1个中心点6 g/d后，情况不再如此，显示出U形响应。在血小板和低密度脂蛋白中观察到抗氧化作用，认为氧化还原状态在其与动脉粥样硬化的关系中至关重要。其次，DHA的氧化产物，特别是由脂氧合酶产生的保护素，被认为具有影响血小板和白细胞的潜力。它的结论是，DHA是一个有趣的营养，以减少动脉粥样硬化血栓形成，可能通过补充机制，涉及DHA的脂氧合酶产品。
DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1g/d, DHA proved to be effective in lowering blood platelet function and exhibited an 'antioxidant' effect. However, this was no longer the case following 1 center dot 6g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA.