Matrix-assisted laser desorption/ionization by using femtosecond laser pulses in the near-infrared wavelength regime.

Matrix-assisted laser desorption/ionization by using femtosecond laser pulses in the near-infrared wavelength regime.
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通过使用近红外波长范围内的飞秒激光脉冲进行基质辅助激光解吸/电离。

DOI:
10.1002/rcm.3974
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发表时间:
2009
期刊:
Rapid communications in mass spectrometry : RCM
影响因子:
--
通讯作者:
A. Lindinger
A. Lindinger
中科院分区:
--
文献类型:
--
作者:
J. Wichmann;C. Lupulescu;L. Wöste;A. Lindinger

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在以800 nm为中心的近红外光谱范围内照射飞秒激光脉冲,并使用具有紫外吸收带的标准MALDI矩阵,观察到基质辅助激光解吸/电离(MALDI)信号。研究了这种新现象对激光脉冲能量的依赖关系,并与近紫外激光脉冲的MALDI进行了比较。我们的观察表明,当样品被超短激光脉冲照射时,多光子吸收/电离可能是MALDI过程中的一个主要问题。
We observe a substantial matrix-assisted laser desorption/ionization (MALDI) signal when irradiating femtosecond laser pulses in the near-infrared spectral range centered around 800 nm and using standard MALDI matrices with absorption bands in the ultraviolet (UV) regime. The laser pulse energy dependence of this novel phenomenon is investigated in comparison with MALDI with near-UV laser pulses. Our observations show that multiphoton absorption/ionization could be a major issue among the MALDI processes when the sample is irradiated with ultra-short laser pulses.
DOI: 10.1021/ac990998k
发表时间: 2000-02-15
影响因子: 7.4
作者:
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通讯作者: Burlingame, AL
DOI: 10.1021/ac0262006
发表时间: 2003-07
影响因子: 7.4
作者:
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通讯作者: Christopher E Von Seggern;Susanne C. Moyer;R. Cotter