Isometric force-related activity in sensorimotor cortex measured with functional MRI
Isometric force-related activity in sensorimotor cortex measured with functional MRI
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DOI：
10.1007/s002210050437
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发表时间：
1998-07-01
影响因子：
2
通讯作者：
Mastaglia, FL
中科院分区：
文献类型：
--
作者：
Thickbroom, GW;Phillips, BA;Mastaglia, FL
在持续的手指屈曲任务中，在与最大自愿收缩相关的多个力水平下，通过成像研究了来自初级感觉运动皮层的等长力相关功能磁共振成像（fMRI）信号。随着力的增加，沿着中央沟可以检测到fMRI信号的范围增加，跨体素的求和信号也增加，但这些参数的关联方式是，每个体素的信号对于每个力的水平都是相似的。结果表明，增加的神经元放电和皮质运动细胞的募集与增加的自愿等长努力有关，这反映在一个相对恒定的fMRI信号在更大体积的皮层上的扩张上，而不是在一个特定的限定区域的反应幅度的增加上，这可能是由于在更广泛的皮层区域灌注了更多的富氧血液。
Isometric force-related functional magnetic resonance imaging (fMRI) signals from primary sensorimotor cortex were investigated by imaging during a sustained finger flexion task at a number of force levels related to maximum voluntary contraction. With increasing levels of force, there was an increase in the extent along the central sulcus from which a fMRI signal could be detected and an increase in the summed signal across voxels, but these parameters were related in such a way that the signal from each voxel was similar for each level of force. The results suggest that increased neuronal firing and recruitment of corticomotor cells associated with increased voluntary isometric effort are reflected in an expansion of a relatively constant fMRI signal over a greater volume of cortex, rather than an increase in the magnitude of the response in a particular circumscribed region, possibly due to perfusion of an increase in oxygen-enriched blood over a wider region of the cortex.