Evaluation of T cell stimulation by thyrotropin-receptor epitopes in Graves' disease.
Evaluation of T cell stimulation by thyrotropin-receptor epitopes in Graves' disease.
复制标题
格雷夫斯病中促甲状腺素受体表位对 T 细胞刺激的评估。
DOI：
10.1007/bf03345679
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发表时间：
2009
影响因子：
5.4
通讯作者：
Hennessey,JV
中科院分区：
文献类型：
--
作者：
DeGroot,LJ;Shin,YHa;Pan,D;Gopalakrishnan,G;Hennessey,JV
在格雷夫斯病（GD）中，对TSH受体表位反应的免疫T细胞通过B细胞帮助和细胞毒性促成发病。我们评估了甲状腺功能亢进GD患者治疗前、放射性碘（RAI）给药后6-8周或6-8个月后甲状腺功能正常时以及对照组患者对合成TSH受体表位的T细胞应答。所有的T细胞应答都相对较低，这通常见于人类自身免疫性疾病。甲状腺功能亢进GD患者的反应明显大于对照组，在RAI治疗后6-8周增加，在患者甲状腺功能正常后仍然存在，DR 3+和非DR 3+患者之间没有差异。患者的T细胞对多种不同的表位反应，反应性取决于疾病和治疗的过程。虽然某些表位最常引起T细胞反应性，但我们没有发现单一或少数“显性”表位的证据。
In Graves’ disease (GD) immunized T cells reactive to TSH-receptor epitopes contribute to pathogenesis through B cell help, and cytotoxicity. We evaluated T cell responses to synthetic TSH-receptor epitopes in hyperthyroid patients with GD prior to therapy, at 6–8 weeks after radioactive iodine (RAI) administration, or 6–8 months later when euthyroid, and in control subjects. All T cell responses were relatively low as generally found in human autoimmune diseases. Responses in hyperthyroid GD patients were significantly greater than among controls, were augmented 6–8 weeks after RAI treatment, were still present after patients became euthyroid, and did not differ between DR3+ and non-DR3+ patients. Patient’s T cells reacted to multiple different epitopes, and reactivity differed depending on the course of the disease and treatment. While certain epitopes most commonly cause T cell reactivity, we did not find evidence for a single or few “dominant” epitopes.