Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample
Post-surgical outcomes of patients with chronic kidney disease and end stage renal disease undergoing radical prostatectomy: 10-year results from the US National Inpatient Sample
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接受根治性前列腺切除术的慢性肾病和终末期肾病患者的术后结果：美国国家住院患者样本的 10 年结果
DOI：
10.1186/s12882-019-1455-2
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发表时间：
2019-07-23
期刊：
影响因子：
2.3
通讯作者：
Zhu, Yichen
中科院分区：
文献类型：
--
作者：
Ning, Chen;Hu, Xinyi;Zhu, Yichen
背景慢性肾脏病（CKD）和终末期肾脏病（ESRD）在前列腺癌患者中的特征性不明显。本研究的目的是研究的临床特征和术后结果的患者或没有慢性肾脏病和终末期肾病进行根治性前列腺癌切除术prostate cancer.MethodsThis人口为基础的，回顾性研究使用的患者数据从全国住院病人样本，最大的所有付款人美国住院病人护理数据库。从2005年到2014年，136，790名年龄> 20岁的男性患者被诊断患有前列腺癌并接受了根治性前列腺切除术。术后并发症，术后急性肾损伤（阿基）和泌尿系并发症，住院时间进行了比较，或没有潜在的CKD和ESRD.ResultsAfter调整相关因素后，CKD组的术后并发症的风险显着高于非CKD组。此外，CKD组术后阿基和泌尿系统并发症的风险是非CKD组的5倍。CKD和ESRD组的住院时间均显著长于非CKD组。接受RARP的患者术后并发症的风险低于接受开放性根治性直肠癌切除术的患者，无论是否患有CKD。接受RARP的非CKD和CKD患者的住院时间短于接受开放手术的患者。ConclusionsProstate cancer patients with underlying CKD术后并发症，术后阿基和泌尿系统并发症的风险显着增加，住院时间较长。RARP的使用显著缩短了这些患者的住院时间并减少了并发症。
BackgroundChronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of patients with or without CKD and ESRD undergoing radical prostatectomy for prostate cancer.MethodsThis population-based, retrospective study used patient data from the Nationwide Inpatient Sample, the largest all-payer US inpatient care database. From 2005 to 2014, 136,790 male patients aged > 20 years diagnosed with prostate cancer and who received radical prostatectomy were included. Postoperative complications, postoperative acute kidney injury (AKI) and urinary complications, and length of hospital stay were compared between patients with or without underlying CKD and ESRD.ResultsAfter adjusting for relevant factors, the CKD group had a significantly higher risk of postoperative complications than the non-CKD group. In addition, the CKD group had a 5-times greater risk of postoperative AKI and urinary complications than the non-CKD group. Both CKD and ESRD groups had significantly longer hospital stays than the non-CKD group. Patients receiving RARP had a lower risk of postoperative complications than those who received open radical prostatectomy, regardless of having CKD or not. Both non-CKD and CKD patients receiving RARP had shorter hospital stays than those who received open surgery.ConclusionsProstate cancer patients with underlying CKD had significantly greater risk of postoperative complications, postoperative AKI and urinary complications, and longer hospital stays than those without CKD. The use of RARP significantly shortened hospital stays and reduced complications for these patients.