Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women
Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women
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DOI：
10.1016/j.nut.2006.08.008
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发表时间：
2006-11-01
期刊：
影响因子：
4.4
通讯作者：
Shearer, Martin J.
中科院分区：
文献类型：
--
作者：
Kruger, Marlena C.;Booth, Christine L.;Shearer, Martin J.
目的：比较补充强化脱脂奶制品(高钙脱脂奶)和添加叶黄素(维生素K)对绝经前妇女骨形成和骨吸收指标的影响。方法：82名20~35岁妇女随机分为3组。两组每天饮用两次高钙脱脂牛奶(1000 mg/d)，加或不加叶茶酚(80mg/d)，共16周，第三组不补充。分别于基线、2、12、16周测定骨密度，并测定骨标记物、总骨钙素、I型前胶原N末端多肽和I型胶原C端肽。对照组和补充维生素K组在0、16周测定血清叶醌和去羧化骨钙素。结果：年龄、体质量指数和骨密度的基础值在不同组间无差异。在补充维生素K的妇女中，平均血清叶醌浓度在16周内从0.27升至0.76微克/L(P<；0.05)，而低羧化骨钙素浓度从9.68降至4.46微克/L(P<；0.05)。16wk后，两个补充组的血浆I型胶原C端肽、总骨钙素和I型N端前胶原肽水平较对照组显著降低(I型胶原C端交联肽30%，总骨钙素和I型N端前胶原多肽15%)。结论：绝经前妇女补充强化牛奶可显著降低骨转换。叶黄素强化效果显著。在这项短期研究中，维生素K状况得到改善，但对骨转换没有明显的相加作用。(C)2006 Elsevier Inc.保留所有权利。
Objective: We compared the effect of supplementation with a fortified skimmed milk product (high calcium skim milk) with or without added phylloquinone (vitamin K,) on markers of bone formation and resorption in premenopausal women.Methods: Eighty-two women 20 to 35 y of age were randomly allocated to three groups. Two groups received two daily servings of high calcium skim milk (1000 mg/d of extra calcium) with or without added phylloquinone (80 mu g/d) for 16 wk, and a third control group received no supplementation. Bone density was assessed at baseline and the bone markers, total osteocalcin, type I N-terminal procollagen peptide, and cross-linked C-telopeptide of type I collagen were measured at baseline and at weeks 2, 12, and 16. Serum phylloquinone and undercarboxylated osteocalcin were measured in the control and vitamin K-supplemented groups at weeks 0 and 16.Results: Baseline values for age, body mass index, and bone density did not differ across groups. In vitamin K-supplemented women, mean serum phylloquinone concentrations increased from 0.27 to 0.76 mu g/L (P < 0.05) and undercarboxylated osteocalcin concentrations decreased from 9.68 to 4.46 mu g/L (P < 0.05) over 16 wk. Plasma cross-linked C-telopeptide of type I collagen, total osteocalcin, and type I N-terminal procollagen peptide levels decreased significantly in both supplemented groups compared with the control group over 16 wk (cross-linked C-telopeptide of type I collagen >30%, total osteocalcin and type I N-terminal procollagen peptide >15%).Conclusion: Fortified milk supplementation in premenopausal women reduced bone turnover significantly. Phylloquinone fortification substantially. improved vitamin K status but had no demonstrable additive effect on bone turnover in this short-term study. (C) 2006 Elsevier Inc. All rights reserved.