Prostaglandins and cyclic AMP in epidermis
Prostaglandins and cyclic AMP in epidermis
复制标题
表皮中的前列腺素和环磷酸腺苷
DOI：
10.1111/j.1365-2133.1975.tb03097.x
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发表时间：
1975
影响因子：
10.3
通讯作者：
V. Levine
中科院分区：
文献类型：
--
作者：
K. Adachi;K. Yoshikawa;K. Halprin;V. Levine
前列腺素E1和E2刺激银屑病患者的猪表皮和人表皮中的环AMP积累。前列腺素A1、A2和F2α相对无效。这种刺激不受β受体阻滞剂（普萘洛尔）的抑制，并且前列腺素E2和肾上腺素的刺激是相加的，这一事实表明每种药物独立地作用于表皮腺苷酸环化酶系统。换句话说，E1和E2作用于表皮中腺苷酸环化酶β受体以外的位点。E1和E2的刺激不是相加的，因此它们可能作用于同一部位。前列腺素E的浓度高于3 × 10−7 M时，可有效引起刺激。该浓度可能在生理范围内，并且内源性前列腺素水平在控制细胞内环AMP水平中的作用不可忽视。
Prostaglandins E1 and E2 stimulate cyclic AMP accumulation in pig epidermis and in human epidermis from patients with psoriasis. Prostaglandins A1, A2 and F2α are relatively ineffective. The fact that this stimulation is not inhibited by a β‐blocker (propranolol) and that the stimulation by prostaglandin E2 and adrenaline is additive indicates that each drug acts independently on the epidermal adenyl cyclase system. In other words, prostaglandins E1 and E2 act on a site other than the β‐receptor of adenyl cyclase in epidermis. The stimulation by prostaglandins E1 and E2 is not additive; hence they probably act on the same site. Concentrations of prostaglandin E above 3 × 10−7 M are effective in causing stimulation. This concentration may be within the physiological range and the contribution of endogenous prostaglandin levels in the control of intracellular cyclic AMP levels cannot be disregarded.