VE-cadherin: at the front, center, and sides of endothelial cell organization and function.
VE-cadherin: at the front, center, and sides of endothelial cell organization and function.
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DOI：
10.1016/j.ceb.2010.07.006
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发表时间：
2010-10
影响因子：
7.5
通讯作者：
Nelson WJ
中科院分区：
文献类型：
--
作者：
Harris ES;Nelson WJ
内皮细胞形成细胞-细胞粘附结构，称为粘附和紧密连接，维持组织完整性，但在炎症反应期间和血管生成期间的细胞重塑期间必须对白细胞迁移保持动态。本综述将重点关注血管内皮 (VE)-钙粘蛋白，这是一种粘附连接复合物的内皮特异性细胞间粘附蛋白。 VE-钙粘蛋白在内皮屏障功能和血管生成中发挥关键作用，因此 VE-钙粘蛋白的可用性和功能受到严格调节。 VE-cadherin also participates directly and indirectly in intracellular signaling pathways that control cell dynamics and cell cycle progression.在这里，我们重点介绍最近的工作，这些工作增进了我们对多种调节和信号传导机制的理解，这些调节和信号传导机制集中在 VE-钙粘蛋白上，并对内皮屏障功能和血管生成重塑产生影响。
Endothelial cells form cell-cell adhesive structures, called adherens and tight junctions, which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the inflammatory response and cellular remodeling during angiogenesis. This review will focus on Vascular Endothelial (VE)-cadherin, an endothelial-specific cell-cell adhesion protein of the adherens junction complex. VE-cadherin plays a key role in endothelial barrier function and angiogenesis, and consequently VE-cadherin availability and function are tightly regulated. VE-cadherin also participates directly and indirectly in intracellular signaling pathways that control cell dynamics and cell cycle progression. Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling.
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影响因子：
4
作者：
Dejana, Elisabetta;Orsenigo, Fabrizio;Lampugnani, Maria Grazia
通讯作者：
Lampugnani, Maria Grazia
影响因子：
3.7
作者：
Carter, W. Bradford;Niu, Guilian;Muffly, Barbara J.
通讯作者：
Muffly, Barbara J.
DOI：
10.1083/jcb.200907135
发表时间：
2010-03-22
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cain RJ;Vanhaesebroeck B;Ridley AJ
通讯作者：
Ridley AJ
影响因子：
9.2
作者：
Abraham, Sabu;Yeo, Margaret;Mavria, Georgia
通讯作者：
Mavria, Georgia
DOI：
10.1073/pnas.0611510104
发表时间：
2007-02-27
影响因子：
11.1
作者：
Dominguez, Melissa G.;Hughes, Virginia C.;Gale, Nicholas W.
通讯作者：
Gale, Nicholas W.