Agouti-related peptide-expressing neurons are mandatory for feeding
Agouti-related peptide-expressing neurons are mandatory for feeding
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DOI：
10.1038/nn1548
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发表时间：
2005-10-01
影响因子：
25
通讯作者：
Brüning, JC
中科院分区：
文献类型：
--
作者：
Gropp, E;Shanabrough, M;Brüning, JC
下丘脑弓状核内神经肽Y（neuropeptide Y，NPY）和刺鼠相关肽（agouti-related peptide，AgRP）的表达受多种激素的调节。然而，编码NPY和/或AgRP的基因的失活对小鼠的食物摄入没有影响。在这里，我们表明，诱导选择性消融的AgRP表达的神经元在成年小鼠的结果在急性减少喂养，这些神经元在调节能量稳态的关键作用，展示了直接的证据。
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide ( AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.