CDNA CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN BETA-ADRENERGIC-RECEPTOR KINASE
CDNA CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN BETA-ADRENERGIC-RECEPTOR KINASE
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DOI：
10.1016/0014-5793(91)80568-n
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发表时间：
1991-05-20
期刊：
影响因子：
3.5
通讯作者：
LEFKOWITZ, RJ
中科院分区：
文献类型：
--
作者：
BENOVIC, JL;STONE, WC;LEFKOWITZ, RJ
The beta-adrenergic receptor kinase (beta-ARK) mediates agonist-dependent phosphorylation of the beta-2-adrenergic and related G protein-coupled receptors. A cDNA encoding bovine beta-ARK has recently been isolated. In this work we have isolated a cDNA encoding human beta-ARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine beta-ARK. Chromosomal location of the human beta-ARK gene was determined by correlating the presence of the beta-ARK locus with retention of a specific human chromosome in a rodent-human hybrid panel. This analysis revealed that the human beta-ARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.
