Increased manganese-superoxide dismutase activity in postmortem brain from neuroleptic-treated psychotic patients.
Increased manganese-superoxide dismutase activity in postmortem brain from neuroleptic-treated psychotic patients.
复制标题
接受抗精神病药物治疗的精神病患者死后大脑中锰超氧化物歧化酶活性增加。
DOI：
10.1016/0006-3223(95)00669-9
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Little,KY
中科院分区：
文献类型：
--
作者：
Loven,DP;James,JF;Biggs,L;Little,KY
自由基超氧化物是一种潜在的有毒化学物质，是正常细胞呼吸和其他代谢过程的结果。当自由基破坏膜或游离脂质时，它们产生血清脂质过氧化物，已发现其在精神分裂症患者的血液中升高（Lohr 1991）。根据几个研究者（Michelson et al 1977; Abdalla et al 1986; Reddy et al 1991），但不是所有研究者（Sinet al 1983），红细胞铜锌超氧化物歧化酶（Cu-Zn SOD）活性（将超氧化物转化为过氧化氢）也在精神分裂症患者中升高。增加超氧化物产生或代偿酶活性发生在精神分裂症和/或其他精神病患者的大脑中的可能性以前没有得到解决。本实验验证了精神病患者死后脑组织SOD活性升高的假设。锰SOD和铜SOD测定从额叶和颞叶的患者诊断和治疗精神病的组织样本，并与年龄和死后间隔匹配的对照组进行了类似的测量。尽管患者被认为
The free radical superoxide is a potentially toxic chemical produced as a result of normal cell respiration and other metabolic processes. When free radicals damage membranes or free lipids they produce serum lipid peroxides, which have been found elevated in the blood of schizophrenic patients (Lohr 1991). Erythrocyte copper-zinc superoxide dismutase (Cu-Zn SOD) activity, which converts superoxide to hydrogen peroxide, is also elevated in schizophrenic patients according to several investigators (Michelson et al 1977; Abdalla et al 1986; Reddy et al 1991), but not all (Sinet et al 1983). The possibility that increased superoxide production or compensatory enzyme activity occurs in the brains of schizophrenic and/or other psychotic patients has not been previously addressed. The present experiment tested the hypothesis that SOD activity would be increased in postmortem brain from psychotic subjects. Both Mn SOD and Cu SOD were measured in tissue samples obtained from the frontal and temporal lobes of patients diagnosed and treated for psychotic illnesses, and compared to similar measurements made for age-and postmortem intervalmatched control subjects. Although the patients were believed to