Differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens
Differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens
复制标题
不同病原引起的成人社区获得性肺炎患者炎症标志物模式的差异
DOI：
10.1111/crj.12614
复制
发表时间：
2018-03-01
影响因子：
1.7
通讯作者：
Cao, Bin
中科院分区：
文献类型：
--
作者：
Liu, Meng;Li, Hui;Cao, Bin
引言不同微生物引起的成人社区获得性肺炎(CAP)的炎症标志物模式尚不清楚。目的探讨不同病原菌引起的成人社区获得性肺炎(CAP)患者的炎症标志物模式。方法选取2010年9月至2012年6月有明确病因的成人CAP患者，根据致病病原分为典型细菌、肺炎支原体(MP)和病毒三组。比较各组发病7天内采集的血清中27种细胞因子和杀菌/通透性增加蛋白（BPI）水平。结果共纳入124例血清检测分析，其中典型细菌性肺炎患者10例，MP肺炎患者56例，病毒性肺炎58例。急性肺炎患者中3种(PDGF-BB、IP-10、RANTES)27种细胞因子和BPI水平显着高于健康对照。不同病原体释放不同的炎症标志物模式：典型细菌性肺炎患者BPI、IL-6、IL-8、IL-1r水平最高；而MP引起的患者PDGF-BB、IL-17A、G-CSF水平高于病毒引起的患者。鼻病毒比其他病毒具有更高的炎症反应水平。 PDGF-BB区分MP和病毒感染的曲线下面积(AUC)最大，为0.708。结论急性肺炎时不同病原体释放不同的炎症标志物模式。首次在急性肺炎中观察到PDGF-BB水平显着升高。它表现出更好的区分MP和病毒感染的能力。
IntroductionThe inflammatory marker patterns of community-acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear.ObjectivesWe aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens.MethodsAdult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, Mycoplasma pneumoniae (MP), and viruses. Twenty-seven cytokines and bactericidal/permeability-increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared.ResultsOne hundred twenty-four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF-BB, IP-10, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL-6, IL-8, IL-1r; while patients caused by MP presented higher levels of PDGF-BB, IL-17A, G-CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF-BB to differentiate MP and virus infection was biggest, which was 0.708.ConclusionDistinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF-BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.