Biomimetic Synthesis of ent-(-)-Azonazine and Stereochemical Reassignment of Natural Product
Biomimetic Synthesis of ent-(-)-Azonazine and Stereochemical Reassignment of Natural Product
复制标题
ent-(-)-氮嗪嗪的仿生合成及天然产物的立体化学重组
DOI：
10.1021/ol4015706
复制
发表时间：
2013-09-06
期刊：
影响因子：
5.2
通讯作者：
Yao, Zhu-Jun
中科院分区：
文献类型：
--
作者：
Zhao, Ji-Chen;Yu, Shun-Ming;Yao, Zhu-Jun
首次利用高价碘介导的仿生氧化环化反应构建了高度应变的核心，完成了恩特(-)氮卓的首次全合成。根据完成的合成结果，对天然(+)-氮杂氮的相对构型和绝对构型进行了修正。
The first total synthesis of ent-(-)-azonazine has been accomplished using a hypervalent iodine-mediated biomimetic oxidative cyclization to construct the highly strained core. Based on the results from the completed synthesis, both the relative and absolute configurations of natural (+)-azonazine were revised.