Evolutionary insights into the organization of chromatin structure and landscape of transcriptional regulation in plants
Evolutionary insights into the organization of chromatin structure and landscape of transcriptional regulation in plants
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DOI：
10.1016/j.tplants.2023.11.009
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发表时间：
2024-06-05
影响因子：
20.5
通讯作者：
Wang，Maojun
中科院分区：
文献类型：
--
作者：
Long，Yuexuan;Wendel，Jonathan F.;Wang，Maojun
复杂性状的发展需要涉及多个基因的复杂调控网络的功能和协调。了解三维染色质结构有助于深入了解调控元件对基因表达的调控。可视化染色质组织在调控元件的进化和功能中的作用的潜力在很大程度上仍未被探索。在这里，我们描述了从调控元件序列变异和染色质结构的双重考虑中产生的新观点，特别关注全基因组加倍或多倍体。我们强调层次染色质组织在进化过程中基因调控的重要性。此外，我们还描述了在未来植物调控进化研究中探索染色质组织的策略，使我们能够深入了解调控元件对基因表达的进化影响，从而了解表型。
Development of complex traits necessitates the functioning and coordination of intricate regulatory networks involving multiple genes. Understanding 3D chromatin structure can facilitate insight into the regulation of gene expression by regulatory elements. This potential, of visualizing the role of chromatin organization in the evolution and function of regulatory elements, remains largely unexplored. Here, we describe new perspectives that arise from the dual considerations of sequence variation of regulatory elements and chromatin structure, with a special focus on whole-genome doubling or polyploidy. We underscore the significance of hierarchical chromatin organization in gene regulation during evolution. In addition, we describe strategies for exploring chromatin organization in future investigations of regulatory evolution in plants, enabling insights into the evolutionary influence of regulatory elements on gene expression and, hence, phenotypes.