HIGD1A-mediated dormancy and tumor survival.
HIGD1A-mediated dormancy and tumor survival.
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DOI：
10.1080/23723556.2015.1030537
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发表时间：
2015-10-01
影响因子：
2.1
通讯作者：
Maltepe, Emin
中科院分区：
文献类型：
--
作者：
Ameri, Kurosh;Maltepe, Emin
实体瘤包含缺氧区域，也被剥夺了葡萄糖。癌细胞是如何在如此极端的条件下存活的尚不清楚。在这里，我们讨论了我们最近的发现，即在葡萄糖饥饿期间通过表观遗传机制调节缺氧诱导基因域家族成员1A (HIGD1A)，通过激活休眠机制调节氧气消耗和活性氧的产生，从而使肿瘤细胞存活。
Solid tumors contain regions of anoxia that are also glucose deprived. How cancer cells survive such extreme conditions remains unclear. Here, we discuss our recent findings that regulation of hypoxia inducible gene domain family member 1A (HIGD1A) via epigenetic mechanisms during glucose starvation modulates oxygen consumption and reactive oxygen species production to enable tumor cell survival through the activation of dormancy mechanisms.