Type 2 diabetes and the metabolic syndrome in Japanese Americans
Type 2 diabetes and the metabolic syndrome in Japanese Americans
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DOI：
10.1016/s0168-8227(00)00182-0
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发表时间：
2000-10-01
影响因子：
5.1
通讯作者：
Wahl, PW
中科院分区：
文献类型：
--
作者：
Fujimoto, WY;Bergstrom, RW;Wahl, PW
日裔美国人的2型糖尿病患病率高于日本人。在西雅图进行的研究表明，与“西化”有关的生活方式因素在导致糖尿病易感性方面发挥了作用。这些生活方式因素包括摄入高饱和脂肪的饮食和减少体力活动。其结果是发展成中枢性（内脏）肥胖、胰岛素抵抗和与该胰岛素抵抗代谢综合征相关的其他特征，如血脂异常（大腿甘油三酯、低HDL-胆固醇和小而密的LDL颗粒）、高血压和冠心病。我们推测，胰岛素抵抗叠加在β细胞储备减少的遗传背景上导致日裔美国人的高血糖症和糖尿病。本文回顾了支持这一观点的证据。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Japanese Americans have experienced a higher prevalence of type 2 diabetes than in Japan. Research conducted in Seattle suggests that lifestyle factors associated with 'westernization' play a role in bringing out this susceptibility to diabetes. These lifestyle factors include consumption of a diet higher in saturated fat and reduced physical activity. A consequence of this is the development of central (visceral) adiposity, insulin resistance, and other features associated with this insulin resistance metabolic syndrome, such as dyslipidemia thigh triglycerides, low HDL-cholesterol, and small and dense LDL particles), hypertension, and coronary heart disease. We have postulated that the superimposition of insulin resistance upon a genetic background of reduced beta -cell reserve results in hyperglycemia and diabetes among Japanese Americans. This article reviews evidence that support this view. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.