MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging
MRI correlates of episodic memory in Alzheimer's disease, mild cognitive impairment, and healthy aging
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DOI：
10.1016/j.pscychresns.2010.07.005
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发表时间：
2010-10-30
影响因子：
2.3
通讯作者：
Ebmeier, Klaus P.
中科院分区：
文献类型：
--
作者：
Sexton, Claire E.;Mackay, Clare E.;Ebmeier, Klaus P.
情景记忆是阿尔茨海默病（AD）和轻度认知障碍（MCI）的核心特征。阿尔茨海默病的情景记忆受损源于一个综合网络的功能障碍，涉及灰质和白质病理。我们通过将情景记忆测量与海马体积、分数各向异性（FA）以及扣带和穹窿的平均扩散率（MD）相关联，探讨了AD、MCI和健康衰老中情景记忆的神经相关性。情景记忆与海马体积和扣带和穹窿MD有关。相比之下，情景记忆和FA之间的关联较少。这些发现支持情景记忆和海马回路之间的关系，并表明在AD和MCI的研究中，MD是白质完整性下降的一个比FA更敏感的标志物。此外，MD与海马体积显著相关，表明白质病理并非完全独立于灰质病理。然而，AD和MCI的弥散性差异模式意味着比简单的沃勒氏变性更复杂的病理。2010爱思唯尔爱尔兰有限公司版权所有。
Episodic memory is a core feature of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Impaired episodic memory in AD results from the dysfunction of an integrated network and involves both gray and white matter pathologies. We explored the neural correlates of episodic memory in AD, MCI and healthy aging by correlating a measure of episodic memory with hippocampal volume and fractional anisotropy (FA) and mean diffusivity (MD) of the cingulum and fornix. Episodic memory was associated with hippocampal volume and MD of the cingulum and fornix. In contrast, there were fewer significant associations between episodic memory and FA. These findings support a relationship between episodic memory and hippocampal circuitry, and suggest that MD is a more sensitive marker of decreased white matter integrity in the study of AD and MCI than FA. Furthermore, MD was significantly associated with hippocampal volume, indicating that white matter pathology is not completely independent of gray matter pathology. However, the pattern of diffusivity differences in AD and MCI implies a more complex pathology than simply Wallerian degeneration. (C) 2010 Elsevier Ireland Ltd. All rights reserved.