Quantitative analysis of proteostasis networks: are there applications for dementia?
Quantitative analysis of proteostasis networks: are there applications for dementia?
复制标题
蛋白质稳态网络的定量分析：是否适用于痴呆症？
DOI：
10.1080/14789450.2024.2320807
复制
发表时间：
2024
影响因子：
3.4
通讯作者：
McClatchy,DanielB
中科院分区：
文献类型：
--
作者：
McClatchy,DanielB
痴呆症被定义为两种或两种以上认知功能的进行性下降，导致生活质量下降。目前没有治疗方法可以显着缓解痴呆症的症状或其进展。据世卫组织统计，全世界有5500万人患有痴呆症，预计每年有1000万新病例[1]。三种最常见的痴呆症是阿尔茨海默病（AD）、路易体痴呆症（DLB）和额颞叶痴呆症（FTD）。所有痴呆症的特征都是神经退行性变，年龄是最重要的风险因素。在美国，670万人患有AD，使其成为最常见的痴呆症和65岁以上人群的第五大死亡原因[2]。
Dementia is defined as the progressive decline of two or more cognitive functions that results in a loss of quality of life. There is currently no treatment that can significantly alleviate the symptoms of dementia or its progression. According to WHO, 55 million people worldwide are afflicted with dementia and 10 million new cases are expected each year [1]. The three most common dementias are Alzheimer’s Disease (AD), Dementia with Lewy Body disease (DLB), and Frontotemporal Dementia (FTD). All dementias are characterized by neurodegeneration, with age being the most significant risk factor. In the United States, 6.7 million people suffer from AD, making it the most common dementia and the fifth leading cause of death for people over 65 years old [2].