Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
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DOI：
10.1192/bjp.bp.107.045120
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发表时间：
2008-10-01
影响因子：
10.5
通讯作者：
Takei, Nori
中科院分区：
文献类型：
--
作者：
Tsuchiya, Kenji J.;Matsumoto, Kaori;Takei, Nori
背景先前的研究已经报道了出生时父亲年龄较高与子女患自闭症谱系障碍的风险之间的关系，包括有智力障碍的子女。目的检验出生时父亲年龄较高是否与高功能自闭症谱系障碍的子女(即非智力残疾子女)之间存在关联。参与者包括智商总分为70，患有DSM-IV自闭症或相关诊断的个体。无血缘关系的健康志愿者作为对照。父母的年龄被划分为三个年龄段(即三个年龄段)。通过Logistic回归分析估计优势比和95%可信区间，并对年龄、性别和出生顺序进行调整。父亲年龄的增加，而不是母亲年龄的增加，与高功能自闭症谱系障碍的风险增加有关。在调整协变量后，父亲年龄级别提高一个水平对应的风险增加1.8倍。结论父亲年龄越高，患高功能自闭症谱系障碍的风险越高。
BackgroundPrevious studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability).MethodA case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ >= 70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order.ResultsEighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.