Angiotensin II induces vascular smooth muscle cell replication independent of blood pressure.
Angiotensin II induces vascular smooth muscle cell replication independent of blood pressure.
复制标题
血管紧张素 II 诱导血管平滑肌细胞复制，与血压无关。
DOI：
10.1161/01.hyp.31.6.1331
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Schwartz,SM
中科院分区：
文献类型：
--
作者：
Su,EJ;Lombardi,DM;Siegal,J;Schwartz,SM
本研究的目的是评估血压在血管平滑肌细胞对全身输注血管紧张素II （Ang II）的增殖反应中的作用。我们实验室之前的研究表明，注入Ang II可诱导大鼠肠系膜血管和颈动脉平滑肌细胞增殖。Ang II是一种强血管加压剂，在治疗1周后，以435 ng·kg - 1·min - 1剂量使大鼠收缩压从120升高到200 mm Hg。问题是高血压的发展是否是在肠系膜动脉或颈动脉动脉壁观察到的复制活动的主要因素，或者单独的Ang II是否在没有血压升高的情况下足以刺激这些血管的增殖。在之前的研究中，我们发现Ang II刺激颈动脉和III型和I型肠系膜微血管中的平滑肌细胞复制。本研究表明，虽然给药肼使动物血压恢复正常，但它并不能抑制Ang II的有丝分裂作用。因此，Ang II似乎对细胞增殖有直接影响。
—The purpose of this investigation was to evaluate the role of blood pressure in the proliferative response of vascular smooth muscle cells to systemic infusion of angiotensin II (Ang II). Our laboratory has previously shown that infusion of Ang II induces smooth muscle cell proliferation in rat mesenteric vessels and carotid arteries. Ang II, a strong vasopressor, raised systolic blood pressure in rats from 120 to 200 mm Hg at a dose of 435 ng · kg−1· min−1after 1 week of treatment. The question arises as to whether this development of hypertension is a primary contributor to the replicative activities observed in the arterial wall of the mesenteric arteries or the carotid arteries or whether Ang II alone, without an increase in blood pressure, is sufficient to stimulate proliferation in these vessels. In the previous studies, we found that Ang II stimulated smooth muscle cell replication in the carotid artery and in type III and type I mesenteric microvessels. This study demonstrates that although administration of hydralazine normalizes the animals’ blood pressures, it does not suppress the mitogenic effect of Ang II. Thus, it appears that Ang II has a direct effect on cell proliferation.