Shared and unique neural mechanisms underlying pediatric trichotillomania and obsessive compulsive disorder.
Shared and unique neural mechanisms underlying pediatric trichotillomania and obsessive compulsive disorder.
复制标题
小儿拔毛癖和强迫症背后共有且独特的神经机制。
DOI：
10.1016/j.psychres.2020.113653
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发表时间：
2021
影响因子：
11.3
通讯作者：
Loo,SandraK
中科院分区：
文献类型：
--
作者：
Peris,TaraS;Salgari,Giulia;Perez,Jocelyn;Jurgiel,Joseph;Vreeland,Allison;O'Neill,Joseph;Chang,Susanna;Piacentini,John;Loo,SandraK
背景人们对小儿拔毛癖（TTM）的神经基础知之甚少。我们检查了患有 TTM、OCD 和健康对照 (HC) 的青少年之间的误差相关负性 (ERN) 振幅和 θ-EEG 功率差异。方法在 Eriksen Flanker 任务期间，记录了 63 名儿科参与者（22 名 TTM、22 名强迫症和 19 名 HC）的 40 通道脑电图。来自抑制控制的 EEG 数据用于得出与运动抑制相关的 ERN 幅度和事件相关频谱功率的估计。结果 TTM 和 HC 在额叶和中央区域的大脑活动模式相似，而 TTM 和 OCD 在顶叶区域相似。相对于 TTM 和 HC，OCD 患者的额叶 ERN 振幅明显更大，而 TTM 和 HC 之间没有差异。与 OCD 组相比，TTM 组在额叶和中央区域的 θ 功率更高，在右侧运动皮层和上顶叶区域的 θ 功率也高于两个对照组。在 TTM 中，侧翼任务表现与额叶、中枢和运动皮层的脑电图活动相关，而整体功能和损伤与双侧运动和顶叶皮层的脑电图功率相关。结论根据 TTM 和强迫症的共同和独特的神经机制以及治疗意义对研究结果进行了讨论。
BackgroundLittle is known about the neural underpinnings of pediatric trichotillomania (TTM). We examined error-related negativity (ERN)-amplitude and theta-EEG power differences among youth with TTM, OCD, and healthy controls (HC).MethodsForty channel EEG was recorded from 63 pediatric participants (22 with TTM, 22 with OCD, and 19 HC) during the Eriksen Flanker Task. EEG data from inhibitory control were used to derive estimates of ERN amplitude and event-related spectral power associated with motor inhibition.ResultsTTM and HC were similar in brain activity patterns in frontal and central regions and TTM and OCD were similar in the parietal region. Frontal ERN-amplitude was significantly larger in OCD relative to TTM and HC, who did not differ from each other. The TTM group had higher theta power compared to OCD in frontal and central regions, and higher theta than both comparison groups in right motor cortex and superior parietal regions. Within TTM, flanker task performance was correlated with EEG activity in frontal, central, and motor cortices whereas global functioning and impairment were associated with EEG power in bilateral motor and parietal cortices.ConclusionsFindings are discussed in terms of shared and unique neural mechanisms in TTM and OCD and treatment implications.