Identification of hydroxyalkenals formed from omega-3 fatty acids.
Identification of hydroxyalkenals formed from omega-3 fatty acids.
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鉴定由 omega-3 脂肪酸形成的羟基烯醛。
DOI：
10.1016/0006-291x(90)91435-u
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发表时间：
1990
影响因子：
3.1
通讯作者：
Greene,HL
中科院分区：
文献类型：
--
作者：
Beckman,JK;Howard,MJ;Greene,HL
高毒性脂质过氧化产物，4-羟基壬烯醛，是由omega-6脂肪酸的氢过氧化物分解形成的。本研究采用薄层色谱、高效液相色谱和GC/质谱法分离并鉴定了由omega-3脂肪酸（二十碳五烯酸和二十二碳六烯酸）的氢过氧化物分解形成的类似羟基烯醛。由两种脂肪酸形成的主要羟基烯醛是4-羟基壬烯醛，4-羟基壬烯醛（2,6）二烯醛的二烯类似物，而4-羟基己醛是次要产物。测量特定的omega-3脂质过氧化产物在食用鱼油的研究中可能是重要的。
The highly toxic lipid peroxidation product, 4-hydroxynonenal, is formed from the decomposition of hydroperoxides of omega-6 fatty acids. In this study the analogous hydroxyalkenals formed from the decomposition of hydroperoxides of omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) were isolated and identified using TLC densitometry, HPLC and GC/Mass Spectrometry. The major hydroxyalkenal formed from both fatty acids was a diene analog of 4-hydroxynonenal, 4-hydroxynona(2,6)dienal, while 4-hydroxyhexanal was a minor product. Measurement of specific omega-3 lipid peroxidation products may be important in studies using dietary fish oil.