Locally advanced breast cancer
Locally advanced breast cancer
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DOI：
10.1016/s0889-8588(05)70065-4
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发表时间：
1999-04-01
影响因子：
2.4
通讯作者：
Hortobagyi, GN
中科院分区：
文献类型：
--
作者：
Esteva, FJ;Hortobagyi, GN
局部晚期乳腺癌（LABC）患者的多学科管理在过去三十年中不断发展。化疗（CT）和内分泌治疗的引入与手术和放射治疗（XRT）相结合，改变了这种疾病的自然史。作者讨论了紫杉烷类、新型内分泌治疗和高剂量CT程序在LABC管理中的作用。提出了保乳手术的适应症。LABC的预后和预测肿瘤标志物的作用进行了讨论。
The multidisciplinary management of patients with locally advanced breast cancer (LABC) has evolved over the last three decades. The introduction of chemotherapy (CT) and endocrine therapy in conjunction with surgery and radiation therapy (XRT) have changed the natural history of this disease. The authors discuss the role of the taxanes, novel endocrine therapy, and highdose CT programs in the management of LABC. Indications for breast-conserving surgery are presented. The role of prognostic and predictive tumor markers in LABC is discussed.